ENSDARG00000005481


Danio rerio

Features
Gene ID: ENSDARG00000005481
  
Biological name :nfkbiaa
  
Synonyms : nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
  
Possible biological names infered from orthology : NF-kappa-B inhibitor alpha / NFKBIA / NFKB inhibitor alpha / P25963 / Q9Z1E3
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 16881883
Gene end: 16884737
  
Corresponding Affymetrix probe sets: Dr.7368.1.A1_at (Zebrafish Array)   NM_213184_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000109941
NCBI entrez gene - 406463     See in Manteia.
RefSeq - NM_213184
RefSeq Peptide - NP_998349
swissprot - F1QCG4
ZFIN ID - ZDB-GENE-040426-2227
Ensembl - ENSDARG00000005481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFKBIAENSGALG00000027864Gallus gallus
 NFKBIAENSG00000100906Homo sapiens
 NfkbiaENSMUSG00000021025Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *ENSDARG0000000769355
nfkbie / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon / O00221* / NFKB inhibitor epsilon*ENSDARG0000006836731
nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *ENSDARG0000003008729
bcl3 / B cell CLL/lymphoma 3 / P20749* / Q9Z2F6* / B-cell lymphoma 3 protein homolog *ENSDARG0000008783227
nfkbiz / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta / Q9BYH8* / Q9EST8* / NFKB inhibitor zeta* / NF-kappa-B inhibitor zeta *ENSDARG0000010209721
zgc:113279ENSDARG0000009953313


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009615 response to virus IDA
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IGI
 biological_processGO:1901533 negative regulation of hematopoietic progenitor cell differentiation IMP


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hematopoietic cell increased amount , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell increased amount , abnormal
Show

 ZFA:0009046 T cell T cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000076303 usp11 / ubiquitin specific peptidase 11 / P51784* / Q99K46*  / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction






 

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