ENSDARG00000017230


Danio rerio

Features
Gene ID: ENSDARG00000017230
  
Biological name :fbxw11b
  
Synonyms : F-box and WD repeat domain containing 11b / fbxw11b
  
Possible biological names infered from orthology : F-box and WD repeat domain containing 11 / F-box/WD repeat-containing protein 11 / FBXW11 / Q5SRY7 / Q9UKB1
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 21444654
Gene end: 21470593
  
Corresponding Affymetrix probe sets: Dr.5692.1.S1_at (Zebrafish Array)   NM_213504_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000117181
Ensembl peptide - ENSDARP00000017497
Ensembl peptide - ENSDARP00000145308
NCBI entrez gene - 406825     See in Manteia.
RefSeq - NM_213504
RefSeq - XM_005155294
RefSeq Peptide - NP_998669
swissprot - F6PB05
swissprot - E9QCK5
swissprot - Q6PGW4
ZFIN ID - ZDB-GENE-040426-2903
Ensembl - ENSDARG00000017230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FBXW11ENSGALG00000002229Gallus gallus
 FBXW11ENSG00000072803Homo sapiens
 Fbxw11ENSMUSG00000020271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*ENSDARG0000010480691
fbxw7 / F-box and WD repeat domain containing 7 / Q8VBV4* / Q969H0* / F-box/WD repeat-containing protein 7 *ENSDARG0000006099426
traf7 / TNF receptor-associated factor 7 / Q6Q0C0*ENSDARG0000006020720
fbxw2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSDARG0000000974518
znf106a / zinc finger protein 106a / Q9H2Y7* / Zfp106* / ZNF106* / zinc finger protein 106*ENSDARG0000001665115
fbxw10 / F-box and WD repeat domain containing 10 / CDRT1* / Q5XX13* / O95170* / Q5SUS0* / CMT1A duplicated region transcript 1* / F-box/WD repeat-containing protein 10 *ENSDARG0000008648415
znf106b / zinc finger protein 106bENSDARG0000009194711


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002040 sprouting angiogenesis IGI
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001079 blood vasculature blood vasculature increased branchiness , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel has extra parts of type vascular sprouts , abnormal
intersegmental vessel vascular sprouts disorganized , abnormal
Show

 ZFA:0005559 vascular sprouts vascular sprouts disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / complex / reaction
 ENSDARG00000061710 map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / complex / reaction
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000042688 bora / bora, aurora kinase A activator / Q6PGQ7* / Q8BS90* / Protein aurora borealis *  / complex / reaction
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex / reaction






 

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