ENSDARG00000005612


Danio rerio

Features
Gene ID: ENSDARG00000005612
  
Biological name :aph1b
  
Synonyms : aph1b / APH1B gamma secretase subunit / Q8JHE9
  
Possible biological names infered from orthology : Aph1c / aph-1 homolog B, gamma-secretase subunit / Gamma-secretase subunit APH-1B / Putative gamma-secretase subunit APH-1C / Q8C7N7 / Q8WW43 / Q9DCZ9
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 29176924
Gene end: 29186939
  
Corresponding Affymetrix probe sets: Dr.4447.1.S1_at (Zebrafish Array)   NM_200115_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011743
NCBI entrez gene - 386808     See in Manteia.
RefSeq - NM_200115
RefSeq Peptide - NP_956409
swissprot - Q8JHE9
ZFIN ID - ZDB-GENE-031118-31
Ensembl - ENSDARG00000005612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APH1BENSG00000138613Homo sapiens
 Aph1bENSMUSG00000032375Mus musculus
 Aph1cENSMUSG00000053040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:114200 / APH1A* / Q96BI3* / Q8BVF7* / Gamma-secretase subunit APH-1A * / aph-1 homolog A, gamma-secretase subunit*ENSDARG0000010063362


Protein motifs (from Interpro)
Interpro ID Name
 IPR009294  Gamma-secretase subunit Aph-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IBA
 biological_processGO:0007220 Notch receptor processing IBA
 biological_processGO:0016485 protein processing IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070765 gamma-secretase complex IBA
 molecular_functionGO:0004175 endopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite shape , abnormal
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 ZFA:0001071 presumptive neural retina presumptive neural retina molecular quality , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015540 psen2 / Q90ZE4 / presenilin 2 / P49810*  / complex
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000004870 psen1 / presenilin 1 / P49768* / P49769*  / complex
 ENSDARG00000068698 psenen / Q8JHF0 / presenilin enhancer gamma secretase subunit / Q9NZ42* / Q9CQR7* / AD000671.1* / Gamma-secretase subunit PEN-2 *  / complex






 

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