ENSDARG00000015540
Danio rerio membrane psen2 peptidase notch cell activity presenilin proteolysis signal protein signaling processing brain development melanocyte golgi nucleus endoplasmic reticulum integral component region endopeptidase activation ventricle peptide ectodomain calcium ion transport pathway
Features Gene ID: ENSDARG00000015540 Biological name :psen2 Synonyms : presenilin 2 / / Possible biological names infered from orthology : P49810 Species: Danio rerio Chr. number: 1 Strand: -1 Band: Gene start: 51048975 Gene end: 51062405 Corresponding Affymetrix probe sets: Dr.8171.1.S1_at (Zebrafish Array) NM_131514_at (Zebrafish Genome Array with custom cdf files) Cross references: Ensembl peptide - ENSDARP0000001179158026
See in Manteia .
NM_131514 NP_571589 Q90ZE4 ZDB-GENE-000330-9 ENSDARG00000015540
See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl )Protein motifs (from Interpro )Gene Ontology (GO ) nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen compound metabolic process primary metabolic process organic substance metabolic process establishment of localization cell communication cellular response to stimulus cellular metabolic process anatomical structure development cellular developmental process developmental pigmentation cell death nitrogen comnitrogen compound metabolic process primary metaprimary metabolic process organic subsorganic substance metabolic process establishmenestablishment of localization cell communicell communication cellular rescellular response to stimulus cellular metcellular metabolic process anatomical sanatomical structure development cellular devcellular developmental process developmentadevelopmental pigmentation cell deathcell death catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a proteincatalytic activity, acting on a protein hydrolase activityhydrolase activity cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cell membrane organelle supramolecular complex synapse cellcell membranemembrane organelleorganelle supramolecular complexsupramolecular complex synapsesynapse
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) ZFA:0000008 brain brain hydrocephalic , abnormal
Show ZFA:0000029 hindbrain hindbrain hydrocephalic , abnormal
Show ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
Show ZFA:0000128 midbrain midbrain hydrocephalic , abnormal
Show ZFA:0000159 tectal ventricle tectal ventricle increased size , abnormal
Show ZFA:0001094 whole organism whole organism decreased size , abnormal
Show ZFA:0001115 trunk trunk melanocyte decreased amount , abnormal
Show ZFA:0001117 post-vent region post-vent region melanocyte decreased amount , abnormal
Show ZFA:0005178 DoLA DoLA increased amount , abnormal
Show ZFA:0009091 melanocyte melanocyte spatial pattern , abnormal
Show ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
Show ZFA:0009248 neuron neuron increased amount , abnormal
Show
Interacting proteins (from Reactome ) ENSDARG00000015540 psen2 / Q90ZE4 / presenilin 2 / P49810* / complex ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor* / reaction ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor* / reaction ENSDARG00000005612 aph1b / Q8JHE9 / APH1B gamma secretase subunit / Aph1c* / Q9DCZ9* / Q8C7N7* / Q8WW43* / Gamma-secretase subunit APH-1B * / Putative gamma-secretase subunit APH-1C * / aph-1 homolog B, gamma... / complex ENSDARG00000068698 psenen / Q8JHF0 / presenilin enhancer gamma secretase subunit / Q9NZ42* / Q9CQR7* / AD000671.1* / Gamma-secretase subunit PEN-2 * / complex
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