ENSDARG00000027777


Danio rerio

Features
Gene ID: ENSDARG00000027777
  
Biological name :tnfaip3
  
Synonyms : tnfaip3 / tumor necrosis factor, alpha-induced protein 3
  
Possible biological names infered from orthology : P21580 / Q60769 / TNF alpha induced protein 3
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 1182257
Gene end: 1208930
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000032728
Ensembl peptide - ENSDARP00000123481
Ensembl peptide - ENSDARP00000154047
swissprot - E7F165
swissprot - F1QG48
ZFIN ID - ZDB-GENE-100212-2
Ensembl - ENSDARG00000027777
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFAIP3ENSGALG00000013861Gallus gallus
 P21580ENSG00000118503Homo sapiens
 Q60769ENSMUSG00000019850Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTUD7A / si:dkey-37f18.2 / Q8R554* / Q8TE49* / OTU deubiquitinase 7A* / OTU domain-containing protein 7A *ENSDARG0000004555622
otud7b / OTU deubiquitinase 7B / B2RUR8* / Q6GQQ9* / OTU domain-containing protein 7B *ENSDARG0000001722021
zranb1a / zinc finger, RAN-binding domain containing 1a / Q9UGI0* / ZRANB1* / zinc finger RANBP2-type containing 1*ENSDARG0000006025715
A0JMQ9 / zranb1b / zinc finger, RAN-binding domain containing 1bENSDARG0000006319014


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR033478  A20 peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035871 protein K11-linked deubiquitination IBA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0045088 regulation of innate immune response IBA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0070536 protein K63-linked deubiquitination IBA
 biological_processGO:0071108 protein K48-linked deubiquitination IBA
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001114 head head malformed , abnormal
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 ZFA:0001115 trunk trunk necrotic , abnormal
trunk decreased thickness , abnormal
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 ZFA:0001117 post-vent region post-vent region necrotic , abnormal
post-vent region curled , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage shape , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / complex / reaction
 ENSDARG00000010756 nod2 / nucleotide-binding oligomerization domain containing 2 / Q8K3Z0* / Q9HC29* / Nucleotide-binding oligomerization domain-containing protein 2 *  / reaction
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex / reaction
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction






 

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