ENSDARG00000101983


Danio rerio

Features
Gene ID: ENSDARG00000101983
  
Biological name :pkn2
  
Synonyms : pkn2 / protein kinase N2
  
Possible biological names infered from orthology : Q16513 / Q8BWW9 / Serine/threonine-protein kinase N2
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 22416275
Gene end: 22477141
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000134148
Ensembl peptide - ENSDARP00000150658
NCBI entrez gene - 571965     See in Manteia.
swissprot - A0A0R4IJZ0
ZFIN ID - ZDB-GENE-061207-42
Ensembl - ENSDARG00000101983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKN2ENSGALG00000006237Gallus gallus
 PKN2ENSG00000065243Homo sapiens
 Pkn2ENSMUSG00000004591Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:153916 / PKN2 (1 of many) / PKN2* / Q16513* / protein kinase N2*ENSDARG0000010129377
pkn1a / protein kinase N1a / PKN1* / Q16512* / P70268* / protein kinase N1* / Serine/threonine-protein kinase N1 *ENSDARG0000006018458
pkn1b / protein kinase N1b / PKN1* / Q16512* / protein kinase N1*ENSDARG0000006274854
pkn3 / protein kinase N3 / Q6P5Z2* / Q8K045* / Serine/threonine-protein kinase N3 *ENSDARG0000007958553


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
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 ZFA:0001094 whole organism whole organism anatomical axis decreased length , abnormal
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 ZFA:0001114 head head malformed , abnormal
head morphology , abnormal
head decreased size , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage absent , abnormal
cranial cartilage decreased size , abnormal
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 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / complex / reaction
 ENSDARG00000018328 rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / complex / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000021309 rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / complex / reaction






 

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