ENSDARG00000043332


Danio rerio

Features
Gene ID: ENSDARG00000043332
  
Biological name :prkcz
  
Synonyms : prkcz / protein kinase C, zeta
  
Possible biological names infered from orthology : Q02956 / Q05513
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 17554313
Gene end: 17771755
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000063591
swissprot - B0S4T7
ZFIN ID - ZDB-GENE-070511-1
Ensembl - ENSDARG00000043332
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKCZENSGALG00000001270Gallus gallus
 PRKCZENSG00000067606Homo sapiens
 PrkczENSMUSG00000029053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122570
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300839
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838238
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992838
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324336
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225435
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565735
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456134
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872334
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417334
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065134
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920833
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984132
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121928
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720528
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481028
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361227
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552226
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246026
si:ch211-195b13.1ENSDARG0000001662325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034662  Atypical Protein Kinase C zeta, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007097 nuclear migration IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035778 pronephric nephron tubule epithelial cell differentiation IGI
 biological_processGO:0035845 photoreceptor cell outer segment organization IGI
 biological_processGO:0048699 generation of neurons IGI
 biological_processGO:0060042 retina morphogenesis in camera-type eye IGI
 biological_processGO:0090049 regulation of cell migration involved in sprouting angiogenesis IMP
 cellular_componentGO:0005622 intracellular IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer disorganized , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros establishment of epithelial cell apical/basal polarity decreased occurrence , abnormal
pronephros pronephric nephron tubule epithelial cell differentiation process quality , abnormal
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 ZFA:0000152 retina retina lacks all parts of type retinal cone cell , abnormal
retina has fewer parts of type retinal rod cell , abnormal
retina structure , abnormal
retina cellular quality , abnormal
retina neuroepithelial cell positional polarity , abnormal
Show

 ZFA:0000277 scale scale spatial pattern , abnormal
scale size , abnormal
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 ZFA:0000547 mouth mouth position , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
intersegmental vessel sprouting angiogenesis process quality , abnormal
intersegmental vessel endothelial tip cell detached from dorsal aorta , abnormal
intersegmental vessel has extra parts of type endothelial tip cell filopodium, abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule establishment of epithelial cell apical/basal polarity decreased occurrence , abnormal
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 ZFA:0001585 caudal fin principal ray caudal fin principal ray morphology , abnormal
caudal fin principal ray deformed , abnormal
caudal fin principal ray decreased amount , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule endocytosis decreased occurrence , abnormal
pronephric proximal convoluted tubule malformed , abnormal
pronephric proximal convoluted tubule cell differentiation involved in pronephros development process quality , abnormal
pronephric proximal convoluted tubule apoptotic , abnormal
pronephric proximal convoluted tubule apoptotic process increased occurrence , abnormal
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 ZFA:0001621 pronephric proximal straight tubule pronephric proximal straight tubule cell differentiation involved in pronephros development process quality , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic , abnormal
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 ZFA:0009011 neuroblast neuroblast nucleus position , abnormal
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 ZFA:0009241 pigmented epithelial cell pigmented epithelial cell shape , abnormal
pigmented epithelial cell pigment granule mislocalised , abnormal
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 ZFA:0009255 amacrine cell amacrine cell spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction






 

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