ENSMUSG00000029053


Mus musculus

Features
Gene ID: ENSMUSG00000029053
  
Biological name :Prkcz
  
Synonyms : Prkcz / protein kinase C, zeta / Q02956
  
Possible biological names infered from orthology : Q05513
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 155260129
Gene end: 155361361
  
Corresponding Affymetrix probe sets: 10519117 (MoGene1.0st)   10561335 (MoGene1.0st)   1418085_at (Mouse Genome 430 2.0 Array)   1449692_at (Mouse Genome 430 2.0 Array)   1454902_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121675
Ensembl peptide - ENSMUSP00000099467
Ensembl peptide - ENSMUSP00000101249
Ensembl peptide - ENSMUSP00000116042
Ensembl peptide - ENSMUSP00000030922
NCBI entrez gene - 18762     See in Manteia.
MGI - MGI:97602
RefSeq - XM_017320042
RefSeq - NM_001039079
RefSeq - NM_001355178
RefSeq - NM_008860
RefSeq - XM_006538655
RefSeq - XM_006538656
RefSeq - XM_011250207
RefSeq Peptide - NP_001342107
RefSeq Peptide - NP_032886
RefSeq Peptide - NP_001034168
swissprot - A2AD74
swissprot - Q02956
swissprot - Q3V341
swissprot - A2AD72
swissprot - A2AD75
Ensembl - ENSMUSG00000029053
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkczENSDARG00000043332Danio rerio
 PRKCZENSGALG00000001270Gallus gallus
 PRKCZENSG00000067606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764372
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503839
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110836
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096536
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288935
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677834
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881634
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194833
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172928
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405628
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969928
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591528
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997027
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034877  Protein kinase C, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IMP
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051222 positive regulation of protein transport IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:1990138 neuron projection extension IGI
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IMP
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IMP
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005815 microtubule organizing center IGI
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IDA
 cellular_componentGO:0043203 axon hillock IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045179 apical cortex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Ppp5ctm1a(EUCOMM)Wtsi/Ppp5ctm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp5ctm1a(EUCOMM)Wtsi/Ppp5ctm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Prkcztm1a(EUCOMM)Wtsi/Prkcztm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025812 Pard3 / Q99NH2 / par-3 family cell polarity regulator / Q8TEW0*  / complex
 ENSMUSG00000061878 Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*  / reaction
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction






 

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