ENSDARG00000028469


Danio rerio

Features
Gene ID: ENSDARG00000028469
  
Biological name :rps6ka2
  
Synonyms : ribosomal protein S6 kinase, polypeptide 2 / rps6ka2
  
Possible biological names infered from orthology : Q15349 / Q9WUT3 / ribosomal protein S6 kinase A2
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 7086735
Gene end: 7157062
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000044704
NCBI entrez gene - 571285     See in Manteia.
swissprot - E7F164
ZFIN ID - ZDB-GENE-090827-1
Ensembl - ENSDARG00000028469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RPS6KA2ENSGALG00000011473Gallus gallus
 Q15349ENSG00000071242Homo sapiens
 Q9WUT3ENSMUSG00000023809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rps6ka1 / ribosomal protein S6 kinase a, polypeptide 1 / P18653* / Q15418* / ribosomal protein S6 kinase A1* / ribosomal protein S6 kinase polypeptide 1*ENSDARG0000003343777
rps6ka3a / ribosomal protein S6 kinase a, polypeptide 3aENSDARG0000003555677
rps6kal / ribosomal protein S6 kinase a, like / Q9UK32* / RPS6KA6* / ribosomal protein S6 kinase A6* / ribosomal protein S6 kinase polypeptide 6*ENSDARG0000003757476
rps6ka3b / ribosomal protein S6 kinase, polypeptide 3bENSDARG0000005792773
rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / Q9Z2B9* / ribosomal protein S6 kinase A4*ENSDARG0000004443642
rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / Q8C050* / ribosomal protein S6 kinase A5*ENSDARG0000006055141
rps6kb1a / ribosomal protein S6 kinase b, polypeptide 1a / Q8BSK8* / P23443* / RPS6KB1* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*ENSDARG0000001839929
rps6kb1b / ribosomal protein S6 kinase b, polypeptide 1b / Q8BSK8* / P23443* / RPS6KB1* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*ENSDARG0000005823029
stk32a / serine/threonine kinase 32A / Q8BGW6* / Q8WU08* / Serine/threonine-protein kinase 32A *ENSDARG000000794998


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000023110 mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*  / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction






 

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