ENSGALG00000004398


Gallus gallus

Features
Gene ID: ENSGALG00000004398
  
Biological name :CARD11
  
Synonyms : CARD11 / caspase recruitment domain family member 11
  
Possible biological names infered from orthology : Caspase recruitment domain-containing protein 11 / Q8CIS0 / Q9BXL7
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 3435737
Gene end: 3475031
  
Corresponding Affymetrix probe sets: Gga.7057.1.S1_at (Chicken Array)   GgaAffx.13169.1.S1_s_at (Chicken Array)   GgaAffx.26202.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059611
Ensembl peptide - ENSGALP00000007002
NCBI entrez gene - 416476     See in Manteia.
RefSeq - XM_015294163
RefSeq - NM_001006161
RefSeq - XM_015294162
RefSeq Peptide - NP_001006161
swissprot - Q5F3W0
swissprot - A0A1L1RLH3
Ensembl - ENSGALG00000004398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 card11ENSDARG00000052741Danio rerio
 CARD11ENSG00000198286Homo sapiens
 Card11ENSMUSG00000036526Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CARD10 / caspase recruitment domain family member 10 / P58660* / Q9BWT7* / Caspase recruitment domain-containing protein 10 *ENSGALG0000004236534
CARD9 / caspase recruitment domain family member 9 / A2AIV8* / Q9H257* / Caspase recruitment domain-containing protein 9 *ENSGALG0000000188919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001478  PDZ domain
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033538  Caspase recruitment domain-containing protein 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IMP
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002377 immunoglobulin production IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IMP
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0042976 activation of Janus kinase activity IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045061 thymic T cell selection IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045577 regulation of B cell differentiation IEA
 biological_processGO:0045580 regulation of T cell differentiation IEA
 biological_processGO:0046649 lymphocyte activation IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070970 interleukin-2 secretion IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032449 CBM complex IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042101 T cell receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IDA
 molecular_functionGO:0050700 CARD domain binding IEA
 molecular_functionGO:0089720 caspase binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / - / complex / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex / reaction
 ENSGALG00000034970 PRKCQ / protein kinase C theta / Q02111* / Q04759*  / complex / reaction
 ENSGALG00000030063 MALT1 / MALT1 paracaspase / Q2TBA3* / Q9UDY8* / Mucosa-associated lymphoid tissue lymphoma translocation *  / complex / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / reaction
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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