ENSGALG00000008407


Gallus gallus

Features
Gene ID: ENSGALG00000008407
  
Biological name :IRAK2
  
Synonyms : interleukin-1 receptor-associated kinase-like 2 / IRAK2
  
Possible biological names infered from orthology : interleukin 1 receptor associated kinase 2 / O43187 / Q8CFA1
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 19471066
Gene end: 19484583
  
Corresponding Affymetrix probe sets: Gga.12723.1.A1_at (Chicken Array)   Gga.12723.1.S1_at (Chicken Array)   Gga.7865.1.S1_at (Chicken Array)   GgaAffx.5299.1.S1_at (Chicken Array)   GgaAffx.5299.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000035437
NCBI entrez gene - 416118     See in Manteia.
RefSeq - NM_001030605
RefSeq - XM_015293126
RefSeq Peptide - NP_001025776
swissprot - F1N826
Ensembl - ENSGALG00000008407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK2ENSG00000134070Homo sapiens
 Irak2ENSMUSG00000060477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*ENSGALG0000000958617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR033611  Interleukin-1 receptor-associated kinase-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001959 regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / complex / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr