ENSG00000154589


Homo sapiens

Features
Gene ID: ENSG00000154589
  
Biological name :LY96
  
Synonyms : LY96 / lymphocyte antigen 96 / Q9Y6Y9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.11
Gene start: 73991352
Gene end: 74029087
  
Corresponding Affymetrix probe sets: 206584_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000284818
Ensembl peptide - ENSP00000430533
NCBI entrez gene - 23643     See in Manteia.
OMIM - 605243
RefSeq - XM_017013299
RefSeq - NM_001195797
RefSeq - NM_015364
RefSeq - XM_011517508
RefSeq Peptide - NP_001182726
RefSeq Peptide - NP_056179
swissprot - Q9Y6Y9
Ensembl - ENSG00000154589
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LY96ENSGALG00000032701Gallus gallus
 Ly96ENSMUSG00000025779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003172  MD-2-related lipid-recognition domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032497 detection of lipopolysaccharide IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0034142 toll-like receptor 4 signaling pathway ISS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0070266 necroptotic process TAS
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IDA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / complex / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / complex / reaction
 ENSG00000160678 P23297 / S100A1 / S100 calcium binding protein A1  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000185303 Q8IWL1 / SFTPA2 / surfactant protein A2  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000133661 SFTPD / P35247 / surfactant protein D  / complex / reaction
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000004139 SARM1 / Q6SZW1 / sterile alpha and TIR motif containing 1  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000122852 Q8IWL2 / SFTPA1 / surfactant protein A1  / complex / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000189403 HMGB1 / P09429 / high mobility group box 1  / complex / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / complex / reaction
 ENSG00000143546 P05109 / S100A8 / S100 calcium binding protein A8  / complex / reaction
 ENSG00000163220 P06702 / S100A9 / S100 calcium binding protein A9  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / complex / reaction






 

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