ENSG00000126456


Homo sapiens

Features
Gene ID: ENSG00000126456
  
Biological name :IRF3
  
Synonyms : interferon regulatory factor 3 / IRF3 / Q14653
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49659569
Gene end: 49665875
  
Corresponding Affymetrix probe sets: 202621_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470140
Ensembl peptide - ENSP00000469113
Ensembl peptide - ENSP00000470069
Ensembl peptide - ENSP00000470431
Ensembl peptide - ENSP00000470436
Ensembl peptide - ENSP00000470512
Ensembl peptide - ENSP00000470905
Ensembl peptide - ENSP00000471358
Ensembl peptide - ENSP00000471402
Ensembl peptide - ENSP00000471517
Ensembl peptide - ENSP00000471896
Ensembl peptide - ENSP00000472223
Ensembl peptide - ENSP00000472582
Ensembl peptide - ENSP00000472601
Ensembl peptide - ENSP00000472700
Ensembl peptide - ENSP00000473128
Ensembl peptide - ENSP00000473176
Ensembl peptide - ENSP00000473232
Ensembl peptide - ENSP00000310127
Ensembl peptide - ENSP00000366339
Ensembl peptide - ENSP00000366344
Ensembl peptide - ENSP00000400378
Ensembl peptide - ENSP00000468911
Ensembl peptide - ENSP00000469067
NCBI entrez gene - 3661     See in Manteia.
OMIM - 603734
RefSeq - NM_001197128
RefSeq - NM_001197127
RefSeq - NM_001197126
RefSeq - NM_001197125
RefSeq - NM_001197122
RefSeq - NM_001197123
RefSeq - NM_001197124
RefSeq - XM_017026767
RefSeq - XM_017026766
RefSeq - XM_006723202
RefSeq - XM_006723201
RefSeq - XM_006723200
RefSeq - XM_006723198
RefSeq - XM_006723197
RefSeq - NM_001571
RefSeq Peptide - NP_001184052
RefSeq Peptide - NP_001184051
RefSeq Peptide - NP_001184053
RefSeq Peptide - NP_001184054
RefSeq Peptide - NP_001184055
RefSeq Peptide - NP_001184056
RefSeq Peptide - NP_001184057
RefSeq Peptide - NP_001562
swissprot - M0QZB8
swissprot - M0QZB7
swissprot - M0QYX3
swissprot - M0QYT9
swissprot - M0QXC8
swissprot - M0QX56
swissprot - Q14653
swissprot - M0R3H7
swissprot - M0R3E9
swissprot - M0R3C2
swissprot - M0R205
swissprot - M0R0X9
swissprot - M0R007
swissprot - M0R0R8
Ensembl - ENSG00000126456
  
Related genetic diseases (OMIM): 616532 - {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, 616532

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf3ENSDARG00000076251Danio rerio
 Irf3ENSMUSG00000003184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRF5 / Q13568 / interferon regulatory factor 5ENSG0000012860423
IRF6 / O14896 / interferon regulatory factor 6ENSG0000011759522
IRF7 / Q92985 / interferon regulatory factor 7ENSG0000018550722
IRF4 / Q15306 / interferon regulatory factor 4ENSG0000013726520
IRF8 / Q02556 / interferon regulatory factor 8ENSG0000014096819
IRF9 / Q00978 / interferon regulatory factor 9ENSG0000021392816
IRF1 / P10914 / interferon regulatory factor 1ENSG0000012534714
IRF2 / P14316 / interferon regulatory factor 2ENSG0000016831012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032479 regulation of type I interferon production TAS
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production ISS
 biological_processGO:0032728 positive regulation of interferon-beta production TAS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0039530 MDA-5 signaling pathway TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045351 type I interferon biosynthetic process IEA
 biological_processGO:0045358 negative regulation of interferon-beta biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050689 negative regulation of defense response to virus by host IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051607 defense response to virus ISS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0071888 macrophage apoptotic process TAS
 biological_processGO:0097300 programmed necrotic cell death IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000110042 DTX4 / Q9Y2E6 / deltex E3 ubiquitin ligase 4  / complex / reaction
 ENSG00000127445 PIN1 / Q13526 / peptidylprolyl cis/trans isomerase, NIMA-interacting 1  / complex / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000160505 NLRP4 / Q96MN2 / NLR family pyrin domain containing 4  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000184584 Q86WV6 / TMEM173 / transmembrane protein 173  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / complex / reaction






 

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