ENSG00000088888


Homo sapiens

Features
Gene ID: ENSG00000088888
  
Biological name :MAVS
  
Synonyms : MAVS / mitochondrial antiviral signaling protein / Q7Z434
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 3846799
Gene end: 3876123
  
Corresponding Affymetrix probe sets: 220305_at (Human Genome U133 Plus 2.0 Array)   226495_at (Human Genome U133 Plus 2.0 Array)   229741_at (Human Genome U133 Plus 2.0 Array)   231829_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401980
Ensembl peptide - ENSP00000413749
NCBI entrez gene - 57506     See in Manteia.
OMIM - 609676
RefSeq - NM_001206491
RefSeq - NM_020746
RefSeq Peptide - NP_001193420
RefSeq Peptide - NP_065797
swissprot - Q7Z434
Ensembl - ENSG00000088888
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mavsENSDARG00000069733Danio rerio
 MAVSENSGALG00000040428Gallus gallus
 MavsENSMUSG00000037523Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026148  Mitochondrial antiviral-signalling protein
 IPR031964  Caspase recruitment domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032727 positive regulation of interferon-alpha production IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IDA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IDA
 biological_processGO:0071660 positive regulation of IP-10 production IDA
 biological_processGO:1900063 regulation of peroxisome organization IMP
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0050700 CARD domain binding IPI


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000068308 OTUD5 / Q96G74 / OTU deubiquitinase 5  / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000003400 CASP10 / Q92851 / caspase 10  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction
 ENSG00000160703 NLRX1 / Q86UT6 / NLR family member X1  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000197111 PCBP2 / Q15366 / poly(rC) binding protein 2  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / complex / reaction
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000078747 ITCH / Q96J02 / itchy E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr