ENSG00000068308


Homo sapiens

Features
Gene ID: ENSG00000068308
  
Biological name :OTUD5
  
Synonyms : OTUD5 / OTU deubiquitinase 5 / Q96G74
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.23
Gene start: 48922028
Gene end: 48958386
  
Corresponding Affymetrix probe sets: 1555426_a_at (Human Genome U133 Plus 2.0 Array)   224745_x_at (Human Genome U133 Plus 2.0 Array)   233933_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390767
Ensembl peptide - ENSP00000379969
Ensembl peptide - ENSP00000401629
Ensembl peptide - ENSP00000481335
Ensembl peptide - ENSP00000156084
Ensembl peptide - ENSP00000365671
NCBI entrez gene - 55593     See in Manteia.
OMIM - 300713
RefSeq - XM_017029630
RefSeq - XM_005272622
RefSeq - XM_005278039
RefSeq - XM_005278042
RefSeq - XM_006724537
RefSeq - XM_011543932
RefSeq - XM_011543934
RefSeq - XM_017029628
RefSeq - XM_017029629
RefSeq - NM_001136157
RefSeq - NM_001136158
RefSeq - NM_001136159
RefSeq - NM_017602
RefSeq Peptide - NP_001129631
RefSeq Peptide - NP_060072
RefSeq Peptide - NP_001129629
RefSeq Peptide - NP_001129630
swissprot - Q96G74
swissprot - H7BZQ3
swissprot - A0A087WXV6
swissprot - A0A024QZ09
Ensembl - ENSG00000068308
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otud5aENSDARG00000059006Danio rerio
 otud5bENSDARG00000056840Danio rerio
 Otud5ENSMUSG00000031154Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALG13 / Q9NP73 / ALG13, UDP-N-acetylglucosaminyltransferase subunitENSG0000010190114
OTUD4 / Q01804 / OTU deubiquitinase 4ENSG0000016416414


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain
 IPR031084  OTU domain-containing protein 5/Otubain-like deubiquitinase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0070536 protein K63-linked deubiquitination IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity IDA
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity IDA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IDA


Pathways (from Reactome)
Pathway description
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction






 

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