ENSG00000011485


Homo sapiens

Features
Gene ID: ENSG00000011485
  
Biological name :PPP5C
  
Synonyms : P53041 / PPP5C / protein phosphatase 5 catalytic subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 46346994
Gene end: 46392981
  
Corresponding Affymetrix probe sets: 201979_s_at (Human Genome U133 Plus 2.0 Array)   215705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375786
Ensembl peptide - ENSP00000434329
Ensembl peptide - ENSP00000012443
NCBI entrez gene - 5536     See in Manteia.
OMIM - 600658
RefSeq - XM_017026935
RefSeq - NM_001204284
RefSeq - NM_006247
RefSeq Peptide - NP_001191213
RefSeq Peptide - NP_006238
swissprot - P53041
swissprot - A0A024R0Q7
swissprot - A8MU39
swissprot - H0YDU8
Ensembl - ENSG00000011485
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp5cENSDARG00000034313Danio rerio
 Ppp5cENSMUSG00000003099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPEF2 / O14830 / protein phosphatase with EF-hand domain 2ENSG0000015619429
PPEF1 / O14829 / protein phosphatase with EF-hand domain 1ENSG0000008671727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR011236  Serine/threonine protein phosphatase 5
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013235  PPP domain
 IPR019734  Tetratricopeptide repeat
 IPR027363  Methylthioribose-1-phosphate isomerase, N-terminal
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010288 response to lead ion ISS
 biological_processGO:0016576 histone dephosphorylation IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation TAS
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1904550 response to arachidonic acid ISS
 biological_processGO:2000324 positive regulation of glucocorticoid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:1990635 proximal dendrite IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISS
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IPI


Pathways (from Reactome)
Pathway description
Negative regulation of MAPK pathway
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr