ENSDARG00000102741


Danio rerio

Features
Gene ID: ENSDARG00000102741
  
Biological name :sumo2b
  
Synonyms : Q6DHL4 / small ubiquitin-like modifier 2b / sumo2b
  
Possible biological names infered from orthology : P61956 / P61957 / Q6EEV6 / small ubiquitin-like modifier 2 / small ubiquitin-like modifier 4 / SUMO2 / SUMO4
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 6423274
Gene end: 6441619
  
Corresponding Affymetrix probe sets: Dr.9029.1.S1_at (Zebrafish Array)   NM_001003422_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000131145
Ensembl peptide - ENSDARP00000137571
NCBI entrez gene - 445027     See in Manteia.
RefSeq - NM_001003422
RefSeq Peptide - NP_001003422
swissprot - Q6DHL4
ZFIN ID - ZDB-GENE-040801-7
Ensembl - ENSDARG00000102741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SUMO2ENSGALG00000007971Gallus gallus
 SUMO2ENSG00000188612Homo sapiens
 SUMO4ENSG00000177688Homo sapiens
 Sumo2ENSMUSG00000020738Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*ENSDARG0000003599392
Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*ENSDARG0000002811991
sumo2a / small ubiquitin-like modifier 2aENSDARG0000010439069
sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *ENSDARG0000004426751


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033950  Sumo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IBA
 biological_processGO:0043009 chordate embryonic development IGI
 biological_processGO:0060216 definitive hemopoiesis IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0031386 protein tag IBA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer cell decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell decreased amount , abnormal
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 ZFA:0001078 thymus thymus lymphoid progenitor cell absent , abnormal
thymus lymphoid progenitor cell aplastic , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
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 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer cell decreased amount , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer cell decreased amount , abnormal
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 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 decreased size , abnormal
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 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 decreased size , abnormal
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 ZFA:0001608 pharyngeal arch 5 pharyngeal arch 5 decreased size , abnormal
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 ZFA:0001609 pharyngeal arch 6 pharyngeal arch 6 decreased size , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 chondrocyte increased size , abnormal
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 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
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 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell cell proliferation decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction / complex
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000014329 npm1a / nucleophosmin 1a / NPM1* / Q61937* / P06748* / nucleophosmin 1*  / reaction
 ENSDARG00000007198 mta1 / metastasis associated 1 / Q13330* / Q8K4B0* / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000060646 senp5 / SUMO1/sentrin specific peptidase 5 / Q6NXL6* / Q96HI0* / Sentrin-specific protease 5 *  / reaction
 ENSDARG00000019213 zgc:136929 / CTBP1* / O88712* / Q13363* / C-terminal binding protein 1*  / reaction
 ENSDARG00000056079 l3mbtl2 / l(3)mbt-like 2 (Drosophila) / P59178* / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit* / Lethal(3)malignant brain tumor-like protein 2 *  / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction / complex
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSDARG00000078574 si:dkey-21c19.3 / SENP1* / Q9P0U3* / P59110* / Sentrin-specific protease 1 * / SUMO1/sentrin specific peptidase 1*  / reaction
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSDARG00000070721 vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*  / reaction
 ENSDARG00000073837 senp2 / SUMO1/sentrin/SMT3 specific peptidase 2 / Gm7275* / Gm5407* / Gm5415* / Q91ZX6* / Q9HC62* / AF366264* / 4930444G20Rik* / cDNA sequence AF366264* / RIKEN cDNA 4930444G20 gene* / Mus ...  / reaction
 ENSDARG00000024488 top2a / DNA topoisomerase II alpha / P11388* / Q01320* / DNA topoisomerase 2-alpha *  / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / complex / reaction
 ENSDARG00000098439 nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / complex / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000034893 rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / reaction
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex
 ENSDARG00000056783 raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / reaction
 ENSDARG00000055359 sp100.1 / SP110 nuclear body protein, tandem duplicate 1 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / complex / reaction
 ENSDARG00000090449 sp100.3 / SP110 nuclear body protein, tandem duplicate 3 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / complex
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSDARG00000104353 nop58 / NOP58 ribonucleoprotein homolog (yeast) / Q6DFW4* / Q9Y2X3* / Nucleolar protein 58 * / NOP58 ribonucleoprotein*  / reaction
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / complex / reaction






 

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