ENSDARG00000070721


Danio rerio

Features
Gene ID: ENSDARG00000070721
  
Biological name :vdrb
  
Synonyms : Q1L673 / vdrb / vitamin D receptor b
  
Possible biological names infered from orthology : P11473 / P48281 / VDR / vitamin D (1,25-dihydroxyvitamin D3) receptor / vitamin D receptor
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 38954733
Gene end: 39006449
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000094891
Ensembl peptide - ENSDARP00000125655
Ensembl peptide - ENSDARP00000126141
NCBI entrez gene - 564511     See in Manteia.
RefSeq - NM_001159985
RefSeq Peptide - NP_001153457
swissprot - I3IT83
swissprot - Q1L673
ZFIN ID - ZDB-GENE-080403-10
Ensembl - ENSDARG00000070721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VDRENSG00000111424Homo sapiens
 VdrENSMUSG00000022479Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948349
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976637
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292333
nr1h4 / nuclear receptor subfamily 1, group H, member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSDARG0000005774130
nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*ENSDARG0000009843930
thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*ENSDARG0000002116328
thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000000015127
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265427
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104625
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411725
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489325
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678325
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000324  Vitamin D receptor
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0070561 vitamin D receptor signaling pathway IEA
 biological_processGO:0071599 otic vesicle development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008434 calcitriol receptor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070644 vitamin D response element binding IDA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000030 macula utricle macula utricle hair cell decreased amount , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000138 otic placode otic placode decreased distribution , abnormal
otic placode decreased amount , abnormal
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 ZFA:0000431 semicircular canal semicircular canal malformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001617 otolith otolith non-functional , abnormal
Show

 ZFA:0007000 macula saccule macula saccule hair cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction






 

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