ENSDARG00000021163


Danio rerio

Features
Gene ID: ENSDARG00000021163
  
Biological name :thrb
  
Synonyms : Q9PVE4 / thrb / thyroid hormone receptor beta
  
Possible biological names infered from orthology : P10828 / P37242
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 17514631
Gene end: 17658253
  
Corresponding Affymetrix probe sets: Dr.8125.1.S1_at (Zebrafish Array)   DrAffx.2.26.A1_at (Zebrafish Array)   DrAffx.2.26.S1_at (Zebrafish Array)   DrAffx.2.26.S1_s_at (Zebrafish Array)   NM_131340_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000152213
Ensembl peptide - ENSDARP00000152808
Ensembl peptide - ENSDARP00000022899
Ensembl peptide - ENSDARP00000126275
Ensembl peptide - ENSDARP00000131464
Ensembl peptide - ENSDARP00000137456
Ensembl peptide - ENSDARP00000144469
Ensembl peptide - ENSDARP00000149633
Ensembl peptide - ENSDARP00000150484
NCBI entrez gene - 30607     See in Manteia.
RefSeq - NM_131340
RefSeq Peptide - NP_571415
swissprot - J9JI02
swissprot - A0A0R4IEJ5
swissprot - Q9PVE4
swissprot - S6BPQ3
ZFIN ID - ZDB-GENE-990415-268
Ensembl - ENSDARG00000021163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 THRBENSGALG00000011294Gallus gallus
 THRBENSG00000151090Homo sapiens
 ThrbENSMUSG00000021779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265462
thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000000015161
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411726
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678326
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489325
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400325
nr1h4 / nuclear receptor subfamily 1, group H, member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSDARG0000005774124
vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*ENSDARG0000007072123
nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*ENSDARG0000009843922
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976621
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104619
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292312
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002154 thyroid hormone mediated signaling pathway IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0048839 inner ear development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070324 thyroid hormone binding ISS


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased pigmentation , abnormal
Show

 ZFA:0000118 hypophysis hypophysis increased amount , abnormal
hypophysis increased distribution , abnormal
hypophysis cell increased volume , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000152 retina retina disorganized , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle increased amount , abnormal
thyroid follicle hyperplastic , abnormal
thyroid follicle increased distribution , abnormal
thyroid follicle cell increased amount , abnormal
thyroid follicle cell increased volume , abnormal
thyroid follicle increased size , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium increased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lacks parts or has fewer parts of type pectoral fin , abnormal
whole organism has extra parts of type thyroid follicle , abnormal
whole organism dead , abnormal
whole organism lacks parts or has fewer parts of type semicircular canal , abnormal
whole organism lacks parts or has fewer parts of type otolith , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton has fewer parts of type cartilage element , abnormal
Show

 ZFA:0009221 UV sensitive photoreceptor cell UV sensitive photoreceptor cell increased amount , abnormal
Show

 ZFA:0009315 horizontal cell horizontal cell synapse increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr