ENSG00000100201


Homo sapiens

Features
Gene ID: ENSG00000100201
  
Biological name :DDX17
  
Synonyms : DDX17 / DEAD-box helicase 17 / Q92841
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.1
Gene start: 38483440
Gene end: 38507660
  
Corresponding Affymetrix probe sets: 208151_x_at (Human Genome U133 Plus 2.0 Array)   208718_at (Human Genome U133 Plus 2.0 Array)   208719_s_at (Human Genome U133 Plus 2.0 Array)   213998_s_at (Human Genome U133 Plus 2.0 Array)   230180_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380033
Ensembl peptide - ENSP00000491776
Ensembl peptide - ENSP00000491244
Ensembl peptide - ENSP00000489029
Ensembl peptide - ENSP00000385536
NCBI entrez gene - 10521     See in Manteia.
OMIM - 608469
RefSeq - NM_006386
RefSeq - NM_001098504
RefSeq Peptide - NP_001091974
RefSeq Peptide - NP_006377
swissprot - Q92841
swissprot - A0A1W2PQ51
swissprot - A0A0U1RQJ0
swissprot - A0A1X7SBZ2
Ensembl - ENSG00000100201
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-156n14.5ENSDARG00000010873Danio rerio
 DDX17ENSGALG00000037360Gallus gallus
 Ddx17ENSMUSG00000055065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX5 / P17844 / DEAD-box helicase 5ENSG0000010865458
DDX42 / Q86XP3 / DEAD-box helicase 42ENSG0000019823133
DDX43 / Q9NXZ2 / DEAD-box helicase 43ENSG0000008000729
DDX53 / Q86TM3 / DEAD-box helicase 53ENSG0000018473528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006396 RNA processing TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0010586 miRNA metabolic process IMP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0030521 androgen receptor signaling pathway IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0045445 myoblast differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003724 RNA helicase activity TAS
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008186 RNA-dependent ATPase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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