ENSG00000002016


Homo sapiens
dnaRAD52repairproteindouble-strandbreakbindingrecombinationviaresponseannealingradcellulardamagesingle-strandcomplexhomologousrecombinaseassemblystimulusprocessinginvolvedoxidativestresshomooligomerizationregulationnucleotide-excisionnucleusnucleoplasmprotein-containingprotein-dna

Features
Gene ID: ENSG00000002016
  
Biological name :RAD52
  
Synonyms : P43351 / RAD52 / RAD52 homolog, DNA repair protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.33
Gene start: 912077
Gene end: 990053
  
Corresponding Affymetrix probe sets: 205647_at (Human Genome U133 Plus 2.0 Array)   210630_s_at (Human Genome U133 Plus 2.0 Array)   211904_x_at (Human Genome U133 Plus 2.0 Array)   236880_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441073
Ensembl peptide - ENSP00000440486
Ensembl peptide - ENSP00000443254
Ensembl peptide - ENSP00000351284
Ensembl peptide - ENSP00000380407
Ensembl peptide - ENSP00000387901
Ensembl peptide - ENSP00000434703
Ensembl peptide - ENSP00000436008
Ensembl peptide - ENSP00000438965
Ensembl peptide - ENSP00000439583
Ensembl peptide - ENSP00000440268
NCBI entrez gene - 5893     See in Manteia.
OMIM - 600392
RefSeq - XM_017019771
RefSeq - NM_001297421
RefSeq - NM_001297422
RefSeq - NM_134424
RefSeq - XM_005253720
RefSeq - XM_005253721
RefSeq - XM_011520990
RefSeq - XM_011520991
RefSeq - XM_011520993
RefSeq - XM_011520995
RefSeq - XM_017019769
RefSeq - XM_017019770
RefSeq - NM_001297419
RefSeq - NM_001297420
RefSeq Peptide - NP_602296
RefSeq Peptide - NP_001284351
RefSeq Peptide - NP_001284348
RefSeq Peptide - NP_001284349
RefSeq Peptide - NP_001284350
swissprot - E9PF95
swissprot - P43351
swissprot - F5GX95
swissprot - F5H1K5
swissprot - F5GX32
swissprot - Q5DR82
Ensembl - ENSG00000002016
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad52ENSDARG00000005274Danio rerio
 RAD52ENSGALG00000039171Gallus gallus
 Rad52ENSMUSG00000030166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004585  DNA recombination/repair protein Rad52
 IPR007232  DNA repair protein Rad52/59/22


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcellular component biogenesisresponse to chemicalnitrogen compounitrogen compound metabolic processresponse to strresponse to stresscellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcellular responcellular response to stimuluscellular componcellular component organizationcellular componcellular component biogenesisresponse to cheresponse to chemical
organic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000730 DNA recombinase assembly IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair TAS
 biological_processGO:0006310 DNA recombination IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IGI
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IDA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0045002 double-strand break repair via single-strand annealing IEA
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:2000819 regulation of nucleotide-excision repair IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0032993 protein-DNA complex IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IMP


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000012061 ERCC1 / P07992 / ERCC excision repair 1, endonuclease non-catalytic subunit  / reaction
 ENSG00000002016 RAD52 / P43351 / RAD52 homolog, DNA repair protein  / complex / reaction
 ENSG00000051180 RAD51 / Q06609 / RAD51 recombinase  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000175595 ERCC4 / Q92889 / ERCC excision repair 4, endonuclease catalytic subunit  / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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