ENSG00000186350


Homo sapiens

Features
Gene ID: ENSG00000186350
  
Biological name :RXRA
  
Synonyms : P19793 / retinoid X receptor alpha / RXRA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.2
Gene start: 134317098
Gene end: 134440585
  
Corresponding Affymetrix probe sets: 202426_s_at (Human Genome U133 Plus 2.0 Array)   202449_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419692
NCBI entrez gene - 6256     See in Manteia.
OMIM - 180245
RefSeq - NM_001291921
RefSeq - NM_001291920
RefSeq - NM_002957
RefSeq Peptide - NP_001278849
RefSeq Peptide - NP_001278850
RefSeq Peptide - NP_002948
swissprot - P19793
swissprot - F1D8Q5
Ensembl - ENSG00000186350
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxraaENSDARG00000057737Danio rerio
 rxrabENSDARG00000035127Danio rerio
 RXRAENSGALG00000042055Gallus gallus
 RxraENSMUSG00000015846Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RXRG / P48443 / retinoid X receptor gammaENSG0000014317170
RXRB / P28702 / retinoid X receptor betaENSG0000020423170
NR2F1 / P10589 / nuclear receptor subfamily 2 group F member 1ENSG0000017574534
NR2F2 / P24468 / nuclear receptor subfamily 2 group F member 2ENSG0000018555134
HNF4G / Q14541 / hepatocyte nuclear factor 4 gammaENSG0000016474933
HNF4A / P41235 / hepatocyte nuclear factor 4 alphaENSG0000010107632
NR2F6 / P10588 / nuclear receptor subfamily 2 group F member 6ENSG0000016011332
NR2C2 / P49116 / nuclear receptor subfamily 2 group C member 2ENSG0000017746331
NR2E3 / Q9Y5X4 / nuclear receptor subfamily 2 group E member 3ENSG0000027857031
NR2C1 / P13056 / nuclear receptor subfamily 2 group C member 1ENSG0000012079830
NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1ENSG0000011233327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000003  Retinoid X receptor/HNF4
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021780  Nuclear/hormone receptor activator site AF-1
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006766 vitamin metabolic process TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008203 cholesterol metabolic process TAS
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019048 modulation by virus of host morphology or physiology IDA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0032526 response to retinoic acid IMP
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IDA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045994 positive regulation of translational initiation by iron IEA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IMP
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IEA
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001972 retinoic acid binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003708 retinoic acid receptor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0004886 9-cis retinoic acid receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042277 peptide binding IDA
 molecular_functionGO:0042809 vitamin D receptor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0044323 retinoic acid-responsive element binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0050692 DBD domain binding IDA
 molecular_functionGO:0050693 LBD domain binding IDA
 molecular_functionGO:0070644 vitamin D response element binding IDA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000012504 NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4  / complex / reaction
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex / reaction
 ENSG00000131759 RARA / P10276 / retinoic acid receptor alpha  / complex
 ENSG00000084676 NCOA1 / Q15788 / nuclear receptor coactivator 1  / complex / reaction
 ENSG00000132170 PPARG / P37231 / peroxisome proliferator activated receptor gamma  / complex / reaction
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex / reaction
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex / reaction
 ENSG00000077092 RARB / P10826 / retinoic acid receptor beta  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex / reaction
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000186951 PPARA / Q07869 / peroxisome proliferator activated receptor alpha  / complex / reaction
 ENSG00000163586 FABP1 / P07148 / fatty acid binding protein 1  / reaction
 ENSG00000112033 PPARD / Q03181 / peroxisome proliferator activated receptor delta  / complex
 ENSG00000164687 FABP5 / Q01469 / fatty acid binding protein 5  / complex / reaction
 ENSG00000172819 RARG / P13631 / retinoic acid receptor gamma  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000140396 NCOA2 / Q15596 / nuclear receptor coactivator 2  / reaction / complex
 ENSG00000143320 CRABP2 / P29373 / cellular retinoic acid binding protein 2  / complex / reaction
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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