ENSDARG00000057737


Danio rerio

Features
Gene ID: ENSDARG00000057737
  
Biological name :rxraa
  
Synonyms : retinoid X receptor, alpha a / rxraa
  
Possible biological names infered from orthology : P19793 / P28700 / retinoid X receptor alpha / RXRA
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 17768174
Gene end: 17944808
  
Corresponding Affymetrix probe sets: Dr.2597.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074930
Ensembl peptide - ENSDARP00000122034
NCBI entrez gene - 555578     See in Manteia.
RefSeq - NM_001161551
RefSeq Peptide - NP_001155023
swissprot - F1Q4V9
swissprot - E9QHW7
ZFIN ID - ZDB-GENE-070314-2
Ensembl - ENSDARG00000057737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RXRAENSGALG00000042055Gallus gallus
 RXRAENSG00000186350Homo sapiens
 RxraENSMUSG00000015846Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rxrab / retinoid x receptor, alpha b / RXRA* / P19793* / P28700* / retinoid X receptor alpha*ENSDARG0000003512776
rxrba / Q7SYN5 / retinoid x receptor, beta a / RXRB* / P28704* / P28702* / retinoid X receptor beta*ENSDARG0000007895473
rxrgb / Q6DHP9 / retinoid X receptor, gamma b / RXRG* / P28705* / P48443* / retinoid X receptor gamma* / Retinoic acid receptor RXR-gamma *ENSDARG0000000469772
rxrbb / retinoid x receptor, beta b / RXRB* / P28702* / P28704* / retinoid X receptor beta*ENSDARG0000000200666
nr2f5 / Q06726 / nuclear receptor subfamily 2, group F, member 5ENSDARG0000003317234
nr2f2 / nuclear receptor subfamily 2, group F, member 2 / P24468* / P43135*ENSDARG0000004092634
Q06725 / nr2f1a / nuclear receptor subfamily 2, group F, member 1a / NR2F1* / P10589* / nuclear receptor subfamily 2 group F member 1*ENSDARG0000005269534
nr2f6a / nuclear receptor subfamily 2, group F, member 6a / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000360732
nr2f1b / Q6PH18 / nuclear receptor subfamily 2, group F, member 1bENSDARG0000001716832
hnf4a / hepatocyte nuclear factor 4, alpha / P41235* / P49698*ENSDARG0000002149432
nr2c2 / nuclear receptor subfamily 2, group C, member 2 / P49116* / P49117*ENSDARG0000004247732
nr2f6b / nuclear receptor subfamily 2, group F, member 6b / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000316531
hnf4g / hepatocyte nuclear factor 4, gamma / Q14541*ENSDARG0000007156531
nr2c1 / nuclear receptor subfamily 2, group C, member 1 / P13056* / Q505F1*ENSDARG0000004552729
nr2e3 / nuclear receptor subfamily 2, group E, member 3 / Q9QXZ7* / Q9Y5X4* / Photoreceptor-specific nuclear receptor *ENSDARG0000004590429
nr2e1 / nuclear receptor subfamily 2, group E, member 1 / Q64104* / Q9Y466*ENSDARG0000001710727
CABZ01057488.1ENSDARG0000010474224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000003  Retinoid X receptor/HNF4
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021780  Nuclear/hormone receptor activator site AF-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SUMOylation of intracellular receptors
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased life span , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019357 Q1AMT3 / fabp1a / fatty acid binding protein 1a, liver / FABP1* / P07148* / fatty acid binding protein 1*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000030449 crabp2b / cellular retinoic acid binding protein 2, b / CRABP2* / P22935* / P29373* / cellular retinoic acid binding protein 2*  / complex / reaction
 ENSDARG00000034893 rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / complex
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000002311 fabp11b / fatty acid binding protein 11b / PMP2* / FABP4* / FABP5* / FABP9* / A6NFH5* / FABP12* / P02689* / P04117* / P15090* / P24526* / Q01469* / Q05816* / Q0Z7S8* / Q9DAK4* / O08716* / G...  / complex / reaction
 ENSDARG00000017299 fabp11a / fatty acid binding protein 11a / PMP2* / FABP4* / FABP5* / FABP9* / A6NFH5* / FABP12* / P02689* / P04117* / P15090* / P24526* / Q01469* / Q05816* / Q0Z7S8* / Q9DAK4* / O08716* / G...  / complex / reaction
 ENSDARG00000058696 tbl1xr1a / transducin (beta)-like 1 X-linked receptor 1a / Q9BZK7* / Q8BHJ5* / TBL1XR1* / transducin beta like 1 X-linked receptor 1* / F-box-like/WD repeat-containing protein TBL1XR1 *  / complex / reaction
 ENSDARG00000008966 tbl1xr1b / transducin (beta)-like 1 X-linked receptor 1b / Q9BZK7* / Q8BHJ5* / TBL1XR1* / transducin beta like 1 X-linked receptor 1* / F-box-like/WD repeat-containing protein TBL1XR1 *  / complex / reaction
 ENSDARG00000056783 raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000060438 tbl1x / transducin beta like 1 X-linked / TBL1Y* / Q9QXE7* / O60907* / Q9BQ87* / transducin beta like 1 Y-linked* / F-box-like/WD repeat-containing protein TBL1X *  / complex / reaction
 ENSDARG00000044525 pparda / peroxisome proliferator-activated receptor delta a / PPARD* / P35396* / Q03181* / peroxisome proliferator activated receptor delta*  / complex
 ENSDARG00000017929 ncoa2 / nuclear receptor coactivator 2 / Q15596* / Q61026*  / complex / reaction
 ENSDARG00000073978 crabp2a / cellular retinoic acid binding protein 2, a / CRABP2* / P22935* / P29373* / cellular retinoic acid binding protein 2*  / complex / reaction
 ENSDARG00000009473 ppardb / peroxisome proliferator-activated receptor delta b / PPARD* / P35396* / Q03181* / peroxisome proliferator activated receptor delta*  / complex
 ENSDARG00000031777 pparaa / peroxisome proliferator-activated receptor alpha a / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / complex / reaction
 ENSDARG00000059227 Q4VBT1 / fabp1b.1 / fatty acid binding protein 1b, tandem duplicate 1 / FABP1* / P07148* / P12710* / fatty acid binding protein 1* / Fatty acid-binding protein, liver *  / reaction
 ENSDARG00000054323 pparab / peroxisome proliferator-activated receptor alpha b / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / complex / reaction
 ENSDARG00000103398 fabp1b.2 / fatty acid binding protein 1b, liver, tandem duplicate 2 / FABP1* / P07148* / P12710* / fatty acid binding protein 1* / Fatty acid-binding protein, liver *  / reaction






 

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