ENSDARG00000045904


Danio rerio
hormonenr2e3nuclearreceptortranscriptionbindingzincfingerdna-templatedpinealsteroidpathwaydnaactivityionligand-bindingdomainreceptor-typenhrgata-typeregulationglanddevelopmentmediatedsignalingnucleusdna-bindingfactorsequence-specificmetalcomplex

Features
Gene ID: ENSDARG00000045904
  
Biological name :nr2e3
  
Synonyms : nr2e3 / nuclear receptor subfamily 2, group E, member 3
  
Possible biological names infered from orthology : Photoreceptor-specific nuclear receptor / Q9QXZ7 / Q9Y5X4
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 22274642
Gene end: 22278655
  
Corresponding Affymetrix probe sets: Dr.7861.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000111061
NCBI entrez gene - 492496     See in Manteia.
RefSeq - NM_001007368
RefSeq Peptide - NP_001007369
swissprot - F1QGF3
ZFIN ID - ZDB-GENE-041114-63
Ensembl - ENSDARG00000045904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR2E3ENSGALG00000002093Gallus gallus
 NR2E3ENSG00000278570Homo sapiens
 Nr2e3ENSMUSG00000032292Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr2e1 / nuclear receptor subfamily 2, group E, member 1 / Q64104* / Q9Y466*ENSDARG0000001710741
nr2f5 / Q06726 / nuclear receptor subfamily 2, group F, member 5ENSDARG0000003317235
nr2f6a / nuclear receptor subfamily 2, group F, member 6a / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000360734
nr2f2 / nuclear receptor subfamily 2, group F, member 2 / P24468* / P43135*ENSDARG0000004092634
Q06725 / nr2f1a / nuclear receptor subfamily 2, group F, member 1a / NR2F1* / P10589* / nuclear receptor subfamily 2 group F member 1*ENSDARG0000005269534
nr2f6b / nuclear receptor subfamily 2, group F, member 6b / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000316533
nr2f1b / Q6PH18 / nuclear receptor subfamily 2, group F, member 1bENSDARG0000001716833
rxraa / retinoid X receptor, alpha a / RXRA* / P19793* / P28700* / retinoid X receptor alpha*ENSDARG0000005773731
rxrbb / retinoid x receptor, beta b / RXRB* / P28702* / P28704* / retinoid X receptor beta*ENSDARG0000000200630
rxrgb / Q6DHP9 / retinoid X receptor, gamma b / RXRG* / P28705* / P48443* / retinoid X receptor gamma* / Retinoic acid receptor RXR-gamma *ENSDARG0000000469729
hnf4a / hepatocyte nuclear factor 4, alpha / P41235* / P49698*ENSDARG0000002149429
rxrab / retinoid x receptor, alpha b / RXRA* / P19793* / P28700* / retinoid X receptor alpha*ENSDARG0000003512729
nr2c2 / nuclear receptor subfamily 2, group C, member 2 / P49116* / P49117*ENSDARG0000004247729
rxrba / Q7SYN5 / retinoid x receptor, beta a / RXRB* / P28704* / P28702* / retinoid X receptor beta*ENSDARG0000007895429
hnf4g / hepatocyte nuclear factor 4, gamma / Q14541*ENSDARG0000007156528
nr2c1 / nuclear receptor subfamily 2, group C, member 1 / P13056* / Q505F1*ENSDARG0000004552726
CABZ01057488.1ENSDARG0000010474221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen componitrogen compound metabolic processbiosynthetic pbiosynthetic processcellular metabcellular metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processanatomical stranatomical structure developmentcell communicacell communicationresponse to enresponse to endogenous stimulusresponse to chresponse to chemicalcellular respocellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activitysignaling receptor activitysignaling receptor activityion bindingion binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021982 pineal gland development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001359 pineal complex pineal complex has fewer parts of type pineal complex photoreceptor cell, abnormal
pineal complex photoreceptor cell fate specification decreased occurrence , abnormal
pineal complex decreased amount , abnormal
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 ZFA:0001360 parapineal organ parapineal organ has extra parts of type parapineal organ neuron, abnormal
parapineal organ neuron fate specification increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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