ENSDARG00000021494


Danio rerio

Features
Gene ID: ENSDARG00000021494
  
Biological name :hnf4a
  
Synonyms : hepatocyte nuclear factor 4, alpha / hnf4a
  
Possible biological names infered from orthology : P41235 / P49698
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 25832689
Gene end: 25865856
  
Corresponding Affymetrix probe sets: Dr.1835.1.S1_at (Zebrafish Array)   Dr.1835.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000112924
Ensembl peptide - ENSDARP00000120529
Ensembl peptide - ENSDARP00000029754
Ensembl peptide - ENSDARP00000109974
swissprot - E9QFX6
swissprot - E9QGV6
swissprot - Q6PHH5
ZFIN ID - ZDB-GENE-030131-1077
Ensembl - ENSDARG00000021494
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HNF4AENSGALG00000004285Gallus gallus
 HNF4AENSG00000101076Homo sapiens
 Hnf4aENSMUSG00000017950Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hnf4g / hepatocyte nuclear factor 4, gamma / Q14541*ENSDARG0000007156565
CABZ01057488.1ENSDARG0000010474239
rxrab / retinoid x receptor, alpha b / RXRA* / P19793* / P28700* / retinoid X receptor alpha*ENSDARG0000003512732
rxraa / retinoid X receptor, alpha a / RXRA* / P19793* / P28700* / retinoid X receptor alpha*ENSDARG0000005773732
rxrba / Q7SYN5 / retinoid x receptor, beta a / RXRB* / P28704* / P28702* / retinoid X receptor beta*ENSDARG0000007895432
rxrbb / retinoid x receptor, beta b / RXRB* / P28702* / P28704* / retinoid X receptor beta*ENSDARG0000000200631
rxrgb / Q6DHP9 / retinoid X receptor, gamma b / RXRG* / P28705* / P48443* / retinoid X receptor gamma* / Retinoic acid receptor RXR-gamma *ENSDARG0000000469731
nr2f5 / Q06726 / nuclear receptor subfamily 2, group F, member 5ENSDARG0000003317229
Q06725 / nr2f1a / nuclear receptor subfamily 2, group F, member 1a / NR2F1* / P10589* / nuclear receptor subfamily 2 group F member 1*ENSDARG0000005269529
nr2f6b / nuclear receptor subfamily 2, group F, member 6b / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000316528
nr2f6a / nuclear receptor subfamily 2, group F, member 6a / NR2F6* / P43136* / P10588* / nuclear receptor subfamily 2 group F member 6*ENSDARG0000000360728
nr2f1b / Q6PH18 / nuclear receptor subfamily 2, group F, member 1bENSDARG0000001716828
nr2f2 / nuclear receptor subfamily 2, group F, member 2 / P24468* / P43135*ENSDARG0000004092628
nr2c2 / nuclear receptor subfamily 2, group C, member 2 / P49116* / P49117*ENSDARG0000004247728
nr2e1 / nuclear receptor subfamily 2, group E, member 1 / Q64104* / Q9Y466*ENSDARG0000001710727
nr2e3 / nuclear receptor subfamily 2, group E, member 3 / Q9QXZ7* / Q9Y5X4* / Photoreceptor-specific nuclear receptor *ENSDARG0000004590427
nr2c1 / nuclear receptor subfamily 2, group C, member 1 / P13056* / Q505F1*ENSDARG0000004552723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:1990798 pancreas regeneration IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001338 intestine intestine decreased amount , abnormal
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 ZFA:0005124 intestinal epithelium intestinal epithelium increased amount , abnormal
intestinal epithelium decreased amount , abnormal
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 ZFA:0005807 intestine lumen intestine lumen decreased volume , abnormal
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 ZFA:0009102 pancreatic B cell pancreatic B cell increased amount , abnormal
pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased area , abnormal
pancreatic B cell regeneration decreased rate , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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