ENSMUSG00000070544


Mus musculus

Features
Gene ID: ENSMUSG00000070544
  
Biological name :Top1
  
Synonyms : DNA topoisomerase 1 / Q04750 / Top1
  
Possible biological names infered from orthology : DNA topoisomerase I / P11387
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H2
Gene start: 160645888
Gene end: 160722764
  
Corresponding Affymetrix probe sets: 10478196 (MoGene1.0st)   1423474_at (Mouse Genome 430 2.0 Array)   1438495_at (Mouse Genome 430 2.0 Array)   1457573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105094
NCBI entrez gene - 21969     See in Manteia.
MGI - MGI:98788
RefSeq - NM_009408
RefSeq Peptide - NP_033434
swissprot - Q04750
Ensembl - ENSMUSG00000070544
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1ENSDARG00000086775Danio rerio
 top1lENSDARG00000070545Danio rerio
 TOP1ENSGALG00000003681Gallus gallus
 TOP1ENSG00000198900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R4U6 / Top1mt / Mus musculus DNA topoisomerase 1, mitochondrial (Top1mt), transcript variant 2, mRNA. / Q969P6* / DNA topoisomerase I mitochondrial*ENSMUSG0000000093449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR018521  DNA topoisomerase I, active site
 IPR025834  Topoisomerase I C-terminal domain
 IPR036202  DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006265 DNA topological change ISO
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IEA
 cellular_componentGO:0031298 replication fork protection complex IBA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043204 perikaryon IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0097100 supercoiled DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr