ENSMUSG00000026826


Mus musculus

Features
Gene ID: ENSMUSG00000026826
  
Biological name :Nr4a2
  
Synonyms : Nr4a2 / Nuclear receptor subfamily 4 group A member 2 / Q06219
  
Possible biological names infered from orthology : P43354
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.1
Gene start: 57106830
Gene end: 57124003
  
Corresponding Affymetrix probe sets: 10482772 (MoGene1.0st)   1433422_at (Mouse Genome 430 2.0 Array)   1433423_at (Mouse Genome 430 2.0 Array)   1447863_s_at (Mouse Genome 430 2.0 Array)   1450749_a_at (Mouse Genome 430 2.0 Array)   1450750_a_at (Mouse Genome 430 2.0 Array)   1455034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028166
Ensembl peptide - ENSMUSP00000108246
Ensembl peptide - ENSMUSP00000108248
Ensembl peptide - ENSMUSP00000138824
NCBI entrez gene - 18227     See in Manteia.
MGI - MGI:1352456
RefSeq - XM_011239034
RefSeq - NM_001139509
RefSeq - NM_013613
RefSeq - XM_011239033
RefSeq Peptide - NP_038641
RefSeq Peptide - NP_001132981
swissprot - Q06219
swissprot - Q3TYI4
swissprot - Q9R1W4
swissprot - A2AQQ8
Ensembl - ENSMUSG00000026826
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a2aENSDARG00000017007Danio rerio
 NR4A2ENSGALG00000012538Gallus gallus
 NR4A2ENSG00000153234Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834158
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*ENSMUSG0000002303454
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*ENSMUSG0000001976820
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*ENSMUSG0000002661020
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*ENSMUSG0000003161820
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*ENSMUSG0000002125519
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495519
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443118
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105517
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187017
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003073  Orphan nuclear receptor, NURR type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010035 response to inorganic substance ISO
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0017085 response to insecticide ISO
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus ISO
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0042053 regulation of dopamine metabolic process IDA
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0042551 neuron maturation IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051866 general adaptation syndrome IMP
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IDA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre/Esr1*)1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Mrc1tm1Mnz/Mrc1tm1Mnz,Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr4a2tm1Niko/Nr4a2tm1Niko
Genetic Background: involves: 129S4/SvJae

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxp3tm4(YFP/icre)Ayr/Foxp3+,Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm4(YFP/icre)Ayr/Foxp3+,Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr4a2tm1Tpe/Nr4a2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr4a2tm1Niko/Nr4a2tm1Niko
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

 MP:0006100 abnormal tegmentum morphology "any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Allelic Composition: Nr4a2tm1Tpe/Nr4a2tm1Tpe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr4a2tm1Niko/Nr4a2tm1Niko
Genetic Background: involves: 129S4/SvJae

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Tg(Lck-cre)1Jtak/0
Genetic Background: Not Specified

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

 MP:0012503 increased midbrain apoptosis "increase in the number of cells of the midbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Fbn1Tsk/Fbn1+,KitW/Kit+
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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