ENSGALG00000012538


Gallus gallus

Features
Gene ID: ENSGALG00000012538
  
Biological name :NR4A2
  
Synonyms : NR4A2 / nuclear receptor subfamily 4 group A member 2
  
Possible biological names infered from orthology : P43354 / Q06219
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 36220884
Gene end: 36228064
  
Corresponding Affymetrix probe sets: GgaAffx.21669.1.S1_at (Chicken Array)   GgaAffx.7957.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020451
Ensembl peptide - ENSGALP00000055138
Ensembl peptide - ENSGALP00000045525
NCBI entrez gene - 424320     See in Manteia.
RefSeq - XM_015290201
RefSeq - XM_015290202
RefSeq - XM_015290203
swissprot - E1C6K9
swissprot - A0A1D5NYR5
Ensembl - ENSGALG00000012538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a2aENSDARG00000017007Danio rerio
 NR4A2ENSG00000153234Homo sapiens
 Nr4a2ENSMUSG00000026826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR4A3 / nuclear receptor subfamily 4 group A member 3 / Q92570* / Q9QZB6*ENSGALG0000001356858
ESRRG / estrogen-related receptor gamma / P62508* / P62509* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSGALG0000000964520
ESRRB / estrogen related receptor beta / O95718* / Q61539* / Steroid hormone receptor ERR2 *ENSGALG0000004177520
NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*ENSGALG0000001003519
ESR1 / estrogen receptor / P03372* / P19785* / estrogen receptor 1*ENSGALG0000001297319
NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*ENSGALG0000003299218
ESR2 / estrogen receptor beta / O08537* / Q92731* / estrogen receptor 2*ENSGALG0000001180117
PGR / progesterone receptor / P06401* / Q00175*ENSGALG0000001719516
AR / androgen receptor / P10275* / P19091*ENSGALG0000003087916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003073  Orphan nuclear receptor, NURR type
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0021986 habenula development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0042551 neuron maturation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051866 general adaptation syndrome IEA
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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