ENSG00000019582


Homo sapiens

Features
Gene ID: ENSG00000019582
  
Biological name :CD74
  
Synonyms : CD74 / CD74 molecule / P04233
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q33.1
Gene start: 150401637
Gene end: 150412929
  
Corresponding Affymetrix probe sets: 1567627_at (Human Genome U133 Plus 2.0 Array)   1567628_at (Human Genome U133 Plus 2.0 Array)   209619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429024
Ensembl peptide - ENSP00000429478
Ensembl peptide - ENSP00000430654
Ensembl peptide - ENSP00000430614
Ensembl peptide - ENSP00000429641
Ensembl peptide - ENSP00000009530
Ensembl peptide - ENSP00000230685
Ensembl peptide - ENSP00000367026
NCBI entrez gene - 972     See in Manteia.
OMIM - 142790
RefSeq - XM_017010090
RefSeq - NM_001025158
RefSeq - NM_001025159
RefSeq - NM_004355
RefSeq - XM_017010089
RefSeq Peptide - NP_004346
RefSeq Peptide - NP_001020329
RefSeq Peptide - NP_001020330
swissprot - H0YBZ2
swissprot - H0YBZ8
swissprot - E7ER71
swissprot - E7EQJ3
swissprot - P04233
swissprot - E7ESL3
Ensembl - ENSG00000019582
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd74aENSDARG00000009087Danio rerio
 CD74ENSGALG00000004594Gallus gallus
 Cd74ENSMUSG00000024610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR011988  MHC class II-associated invariant chain, trimerisation
 IPR015386  MHC class II-associated invariant chain/CLIP, MHC II-interacting
 IPR022339  MHC class II-associated invariant chain
 IPR036613  MHC class II-associated invariant chain, trimerisation domain superfamily
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA
 biological_processGO:0002792 negative regulation of peptide secretion IDA
 biological_processGO:0002830 positive regulation of type 2 immune response IEA
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019883 antigen processing and presentation of endogenous antigen NAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0035691 macrophage migration inhibitory factor signaling pathway IEA
 biological_processGO:0043030 regulation of macrophage activation NAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045058 T cell selection NAS
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045657 positive regulation of monocyte differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IEA
 biological_processGO:0065003 protein-containing complex assembly ISS
 biological_processGO:0070206 protein trimerization IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005773 vacuole IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane TAS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0035692 macrophage migration inhibitory factor receptor complex IDA
 cellular_componentGO:0035693 NOS2-CD74 complex IEA
 cellular_componentGO:0042613 MHC class II protein complex IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0001540 amyloid-beta binding IPI
 molecular_functionGO:0004896 cytokine receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding IDA
 molecular_functionGO:0035718 macrophage migration inhibitory factor binding IPI
 molecular_functionGO:0042289 MHC class II protein binding IEA
 molecular_functionGO:0042609 CD4 receptor binding IPI
 molecular_functionGO:0042658 MHC class II protein binding, via antigen binding groove IDA
 molecular_functionGO:0042802 identical protein binding TAS
 molecular_functionGO:0044183 protein binding involved in protein folding IDA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000127022 CANX / P27824 / calnexin  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000240972 MIF / P14174 / macrophage migration inhibitory factor  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex / reaction
 ENSG00000129354 AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit  / complex
 ENSG00000204252 P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha  / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex / reaction
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000072958 AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit  / complex
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000166747 AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit  / complex
 ENSG00000152056 AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit  / complex
 ENSG00000182287 AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit  / complex
 ENSG00000100280 AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit  / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex / reaction
 ENSG00000100600 LGMN / Q99538 / legumain  / reaction
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000106367 AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit  / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000163131 CTSS / P25774 / cathepsin S  / reaction
 ENSG00000204257 P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha  / reaction
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex / reaction
 ENSG00000242574 P28068 / HLA-DMB / major histocompatibility complex, class II, DM beta  / reaction
 ENSG00000241106 P13765 / HLA-DOB / major histocompatibility complex, class II, DO beta  / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction






 

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