ENSG00000242574


Homo sapiens

Features
Gene ID: ENSG00000242574
  
Biological name :HLA-DMB
  
Synonyms : HLA-DMB / major histocompatibility complex, class II, DM beta / P28068
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32934629
Gene end: 32941070
  
Corresponding Affymetrix probe sets: 203932_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398890
Ensembl peptide - ENSP00000411276
Ensembl peptide - ENSP00000390848
NCBI entrez gene - 3109     See in Manteia.
OMIM - 142856
RefSeq - NM_002118
RefSeq Peptide - NP_002109
swissprot - A0A1V0E3P2
swissprot - H0Y4B8
swissprot - H0Y7A2
swissprot - P28068
Ensembl - ENSG00000242574
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929676.1ENSDARG00000104635Danio rerio
 FO744840.1ENSDARG00000110501Danio rerio
 mhc2bENSDARG00000104730Danio rerio
 mhc2dabENSDARG00000079105Danio rerio
 mhc2dbbENSDARG00000056330Danio rerio
 si:busm1-104n07.3ENSDARG00000074510Danio rerio
 si:busm1-228j01.4ENSDARG00000088872Danio rerio
 si:busm1-228j01.6ENSDARG00000041705Danio rerio
 si:ch73-158p21.3ENSDARG00000101030Danio rerio
 si:zfos-2070c2.3ENSDARG00000076307Danio rerio
 zgc:103700ENSDARG00000116524Danio rerio
 ENSGALG00000034319Gallus gallus
 ENSGALG00000044502Gallus gallus
 BLB1ENSGALG00000000141Gallus gallus
 BLB2ENSGALG00000030940Gallus gallus
 H2-DMb1ENSMUSG00000079547Mus musculus
 H2-DMb2ENSMUSG00000037548Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL645941.2ENSG0000024899354
P13765 / HLA-DOB / major histocompatibility complex, class II, DO betaENSG0000024110625
HLA-DQB1 / major histocompatibility complex, class II, DQ beta 1ENSG0000017934424
P01911 / Q29974 / Q9GIY3 / P04229 / HLA-DRB1 / major histocompatibility complex, class II, DR beta 1ENSG0000019612623
P04440 / HLA-DPB1 / major histocompatibility complex, class II, DP beta 1ENSG0000022386523
P05538 / HLA-DQB2 / major histocompatibility complex, class II, DQ beta 2ENSG0000023262923
Q30154 / HLA-DRB5 / major histocompatibility complex, class II, DR beta 5ENSG0000019850222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000353  MHC class II, beta chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002399 MHC class II protein complex assembly IMP
 biological_processGO:0002503 peptide antigen assembly with MHC class II protein complex IDA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0023026 MHC class II protein complex binding IDA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204252 P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000204257 P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha  / complex
 ENSG00000241106 P13765 / HLA-DOB / major histocompatibility complex, class II, DO beta  / complex






 

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