ENSG00000232629


Homo sapiens

Features
Gene ID: ENSG00000232629
  
Biological name :HLA-DQB2
  
Synonyms : HLA-DQB2 / major histocompatibility complex, class II, DQ beta 2 / P05538
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32756098
Gene end: 32763534
  
Corresponding Affymetrix probe sets: 215536_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415997
Ensembl peptide - ENSP00000390431
Ensembl peptide - ENSP00000396330
Ensembl peptide - ENSP00000410512
NCBI entrez gene - 3120     See in Manteia.
OMIM - 615161
RefSeq - XM_011514561
RefSeq - NM_001198858
RefSeq - NM_001300790
RefSeq - XM_005249051
RefSeq - XM_011514560
RefSeq Peptide - NP_001287719
RefSeq Peptide - NP_001185787
swissprot - P05538
swissprot - H0Y7Y7
swissprot - Q5SR05
swissprot - A2ADX3
Ensembl - ENSG00000232629
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929676.1ENSDARG00000104635Danio rerio
 FO744840.1ENSDARG00000110501Danio rerio
 mhc2bENSDARG00000104730Danio rerio
 mhc2dabENSDARG00000079105Danio rerio
 mhc2dbbENSDARG00000056330Danio rerio
 si:busm1-104n07.3ENSDARG00000074510Danio rerio
 si:busm1-228j01.4ENSDARG00000088872Danio rerio
 si:busm1-228j01.6ENSDARG00000041705Danio rerio
 si:ch73-158p21.3ENSDARG00000101030Danio rerio
 si:zfos-2070c2.3ENSDARG00000076307Danio rerio
 zgc:103700ENSDARG00000116524Danio rerio
 H2-Ab1ENSMUSG00000073421Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLA-DQB1 / major histocompatibility complex, class II, DQ beta 1ENSG0000017934480
Q30154 / HLA-DRB5 / major histocompatibility complex, class II, DR beta 5ENSG0000019850265
P01911 / Q29974 / Q9GIY3 / P04229 / HLA-DRB1 / major histocompatibility complex, class II, DR beta 1ENSG0000019612664
P04440 / HLA-DPB1 / major histocompatibility complex, class II, DP beta 1ENSG0000022386559
P13765 / HLA-DOB / major histocompatibility complex, class II, DO betaENSG0000024110654
P28068 / HLA-DMB / major histocompatibility complex, class II, DM betaENSG0000024257423
AL645941.2ENSG000002489938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000353  MHC class II, beta chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane TAS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0042613 MHC class II protein complex IEA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0032395 MHC class II receptor activity NAS


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
MHC class II antigen presentation
PD-1 signaling
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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