ENSG00000204252


Homo sapiens

Features
Gene ID: ENSG00000204252
  
Biological name :HLA-DOA
  
Synonyms : HLA-DOA / major histocompatibility complex, class II, DO alpha / P06340
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 33004178
Gene end: 33009612
  
Corresponding Affymetrix probe sets: 206313_at (Human Genome U133 Plus 2.0 Array)   211142_x_at (Human Genome U133 Plus 2.0 Array)   216946_at (Human Genome U133 Plus 2.0 Array)   217001_x_at (Human Genome U133 Plus 2.0 Array)   226878_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363946
Ensembl peptide - ENSP00000229829
NCBI entrez gene - 3111     See in Manteia.
OMIM - 142930
RefSeq - NM_002119
RefSeq Peptide - NP_002110
swissprot - A0A1V0E3P0
swissprot - A0A1V0E3P1
swissprot - A0A1V0E3P3
swissprot - A0A1V0E3P6
swissprot - A0A1V0E3P8
swissprot - A0A1V0E3P9
swissprot - A0A1V0E3Q1
swissprot - A0A1V0E3Q2
swissprot - A0A1V0E3Q3
swissprot - A0A1V0E3Q4
swissprot - A0A1V0E3Q5
swissprot - A0A1V0E3Q6
swissprot - A0A1V0E3Q7
swissprot - A0A1V0E3Q8
swissprot - A0A1V0E3R0
swissprot - A0A1V0E3R3
swissprot - A0A1V0E3R4
swissprot - A0A1V0E3R6
swissprot - A0A1V0E3R8
swissprot - A0A1V0E3S0
swissprot - A0A1V0E3S4
swissprot - A0A1V0E3S6
swissprot - A0A1V0E3S7
swissprot - A0A1V0E3T1
swissprot - F6WU08
swissprot - P06340
swissprot - X5CF87
swissprot - A0A1V0E3M7
swissprot - A0A1V0E3N1
swissprot - A0A1V0E3N3
swissprot - A0A1V0E3N6
swissprot - A0A1V0E3N7
Ensembl - ENSG00000204252
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT583723.2ENSDARG00000116565Danio rerio
 CU914776.2ENSDARG00000114601Danio rerio
 si:busm1-194e12.11ENSDARG00000103716Danio rerio
 si:busm1-194e12.8ENSDARG00000103702Danio rerio
 si:busm1-266f07.2ENSDARG00000031745Danio rerio
 si:ch73-211l2.3ENSDARG00000075932Danio rerio
 si:zfos-2070c2.1ENSDARG00000070206Danio rerio
 si:zfos-367g9.1ENSDARG00000074816Danio rerio
 zgc:123107ENSDARG00000101675Danio rerio
 H2-OaENSMUSG00000024334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1ENSG0000023138956
P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1ENSG0000019673555
P01903 / HLA-DRA / major histocompatibility complex, class II, DR alphaENSG0000020428754
P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2ENSG0000023754154
P28067 / HLA-DMA / major histocompatibility complex, class II, DM alphaENSG0000020425727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001003  MHC class II, alpha chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0045580 regulation of T cell differentiation IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0023026 MHC class II protein complex binding IDA
 molecular_functionGO:0032395 MHC class II receptor activity TAS


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction / complex
 ENSG00000204257 P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000242574 P28068 / HLA-DMB / major histocompatibility complex, class II, DM beta  / complex
 ENSG00000241106 P13765 / HLA-DOB / major histocompatibility complex, class II, DO beta  / complex






 

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