ENSG00000205846


Homo sapiens
c-typeCLEC6Alectin-likeimmuneresponsemembranedomainlectinsignalingregulationlinksuperfamilyfoldcd-likestimulatoryreceptorpathwayadaptiveprocessi-kappabkinasenf-kappabinnatecytokinesecretiondefensefungusplasmaintegralcomponent

Features
Gene ID: ENSG00000205846
  
Biological name :CLEC6A
  
Synonyms : CLEC6A / C-type lectin domain containing 6A / Q6EIG7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 8455926
Gene end: 8478330
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000371505
NCBI entrez gene - 93978     See in Manteia.
OMIM - 613579
RefSeq - NM_001317999
RefSeq - NM_001007033
RefSeq Peptide - NP_001007034
RefSeq Peptide - NP_001304928
swissprot - Q6EIG7
Ensembl - ENSG00000205846
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 illr1ENSDARG00000059254Danio rerio
 illr2ENSDARG00000094882Danio rerio
 illr3ENSDARG00000018327Danio rerio
 illr4ENSDARG00000008075Danio rerio
 si:ch211-133n4.11ENSDARG00000094796Danio rerio
 si:ch211-133n4.12ENSDARG00000092749Danio rerio
 si:ch211-133n4.7ENSDARG00000095424Danio rerio
 si:ch211-232p21.6ENSDARG00000089377Danio rerio
 si:ch73-86n18.1ENSDARG00000056379Danio rerio
 Clec4nENSMUSG00000023349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLEC4C / Q8WTT0 / C-type lectin domain family 4 member CENSG0000019817851
CLEC4A / Q9UMR7 / C-type lectin domain family 4 member AENSG0000011172940
CLEC4D / Q8WXI8 / C-type lectin domain family 4 member DENSG0000016652739


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
response to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsecell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to strresponse to stressimmune responseimmune responsecell communicatcell communicationcellular responcellular response to stimulusmacromolecule lmacromolecule localizationestablishment oestablishment of localizationcytokine produccytokine productionresponse to extresponse to external stimulusresponse to bioresponse to biotic stimulus
carbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate bindingcarbohydrate binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response ISS
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050832 defense response to fungus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding ISS


Pathways (from Reactome)
Pathway description
Dectin-2 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction






 

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