ENSG00000166527


Homo sapiens
membraneCLEC4Dc-typeimmuneresponselectin-likereceptorgranulebindingdomainlectinsignalingpathwayneutrophildegranulationlinksuperfamilyfoldcd-likestimulatoryadaptivetcelldifferentiationinvolvedprocessfc-gammadefensebacteriuminnate

Features
Gene ID: ENSG00000166527
  
Biological name :CLEC4D
  
Synonyms : CLEC4D / C-type lectin domain family 4 member D / Q8WXI8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 8509475
Gene end: 8522366
  
Corresponding Affymetrix probe sets: 1552772_at (Human Genome U133 Plus 2.0 Array)   1552773_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371496
Ensembl peptide - ENSP00000299665
NCBI entrez gene - 338339     See in Manteia.
OMIM - 609964
RefSeq - XM_011520633
RefSeq - NM_080387
RefSeq - XM_011520632
RefSeq Peptide - NP_525126
swissprot - Q8WXI8
swissprot - A6NHA5
Ensembl - ENSG00000166527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 illr1ENSDARG00000059254Danio rerio
 illr2ENSDARG00000094882Danio rerio
 illr3ENSDARG00000018327Danio rerio
 illr4ENSDARG00000008075Danio rerio
 si:ch211-133n4.11ENSDARG00000094796Danio rerio
 si:ch211-133n4.12ENSDARG00000092749Danio rerio
 si:ch211-133n4.7ENSDARG00000095424Danio rerio
 si:ch211-232p21.6ENSDARG00000089377Danio rerio
 si:ch73-86n18.1ENSDARG00000056379Danio rerio
 Clec4dENSMUSG00000030144Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLEC4C / Q8WTT0 / C-type lectin domain family 4 member CENSG0000019817840
CLEC6A / Q6EIG7 / C-type lectin domain containing 6AENSG0000020584638
CLEC4A / Q9UMR7 / C-type lectin domain family 4 member AENSG0000011172932


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
response to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to stressimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell activationimmune effector processresponse to external stimulusresponse to biotic stimulusestablishment of localizationresponse to response to stressimmune respoimmune responsecell communicell communicationcellular rescellular response to stimulusanatomical sanatomical structure developmentcellular devcellular developmental processcell activatcell activationimmune effecimmune effector processresponse to response to external stimulusresponse to response to biotic stimulusestablishmenestablishment of localization
protein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingcarbohydrate bindingprotein bindingprotein bindingcarbohydrate bindingcarbohydrate binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002292 T cell differentiation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IEA


Pathways (from Reactome)
Pathway description
Dectin-2 family
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / complex






 

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