ENSGALG00000002661


Gallus gallus
proteinregulationbindingYWHAE-activityionmembranecalciumplasmachannelmitoticdomaindevelopmentresponseheatdephosphorylationexportnucleuspotassiumtransmembranetransporterregulatorhsfactivationlosscentrosomesrecruitmentcentrosomeproteinsconserved

Features
Gene ID: ENSGALG00000002661
  
Biological name :YWHAE
  
Synonyms : 14-3-3 protein epsilon / Q5ZMT0 / YWHAE
  
Possible biological names infered from orthology : P62258 / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 5167612
Gene end: 5187555
  
Corresponding Affymetrix probe sets: GgaAffx.11407.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058130
Ensembl peptide - ENSGALP00000063049
Ensembl peptide - ENSGALP00000058737
Ensembl peptide - ENSGALP00000039133
NCBI entrez gene - 417554     See in Manteia.
RefSeq - NM_001006219
RefSeq - XM_015295739
RefSeq Peptide - NP_001006219
swissprot - F1P2P9
swissprot - A0A1L1RJ11
swissprot - Q5ZMT0
swissprot - A0A1D5PYS5
Ensembl - ENSGALG00000002661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhae1ENSDARG00000006399Danio rerio
 YWHAEENSG00000108953Homo sapiens
 YwhaeENSMUSG00000020849Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...ENSGALG0000003138767
YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...ENSGALG0000000414364
YWHAH / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta / P68510* / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide*ENSGALG0000000674360
YWHAG / 14-3-3 protein gamma / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activ...ENSGALG0000001735860
YWHAQ / Q5ZMD1 / 14-3-3 protein theta / P68254* / P27348* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta*ENSGALG0000001643359
SFN / stratifin / O70456* / P31947*ENSGALG0000002811558


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcellular localizationresponse to stressresponse to abiotic stimulusregulation of biological qualityregulation of molecular functionnitrogennitrogen compound metabolic processcell comcell communicationcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processcellularcellular response to stimuluslocalizalocalization of cellmovementmovement of cell or subcellular componentanatomicanatomical structure developmentcellularcellular developmental processmacromolmacromolecule localizationestablisestablishment of localizationcellularcellular localizationresponseresponse to stressresponseresponse to abiotic stimulusregulatiregulation of biological qualityregulatiregulation of molecular function
channel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activityprotein bindingchannel regulator activitychannel regulator activityprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISS
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0034605 cellular response to heat ISS
 biological_processGO:0035308 negative regulation of protein dephosphorylation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus ISS
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901020 negative regulation of calcium ion transmembrane transporter activity IEA
 biological_processGO:1902309 negative regulation of peptidyl-serine dephosphorylation IEA
 biological_processGO:1905913 negative regulation of calcium ion export across plasma membrane IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050815 phosphoserine residue binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Signaling by Hippo
Regulation of PLK1 Activity at G2/M Transition
Regulation of HSF1-mediated heat shock response
HSF1 activation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
TP53 Regulates Metabolic Genes
AURKA Activation by TPX2
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010412 WWTR1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSGALG00000007308 RAB35 / RAB35, member RAS oncogene family / Q15286* / Q6PHN9*  / reaction
 ENSGALG00000002661 YWHAE / Q5ZMT0 / 14-3-3 protein epsilon / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex






 

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