ENSGALG00000000055


Gallus gallus
regulationLAMTOR3activitycomplexendosomeragulatorproteinactivationtorsignalingcellularlatemembranemtorsignallinglamtormapkklocalizationmolecularfunctionresponseaminoacidstimulusguanyl-nucleotideexchangefactorkinaseactivatorprotein-containingscaffold

Features
Gene ID: ENSGALG00000000055
  
Biological name :LAMTOR3
  
Synonyms : LAMTOR3 / Q5ZIP2 / Ragulator complex protein LAMTOR3
  
Possible biological names infered from orthology : late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / O88653 / Q9UHA4
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 60509422
Gene end: 60514714
  
Corresponding Affymetrix probe sets: Gga.4355.1.S1_at (Chicken Array)   Gga.4355.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048857
Ensembl peptide - ENSGALP00000064354
Ensembl peptide - ENSGALP00000061902
Ensembl peptide - ENSGALP00000060460
Ensembl peptide - ENSGALP00000000069
NCBI entrez gene - 425210     See in Manteia.
RefSeq - NM_001006559
RefSeq Peptide - NP_001006559
swissprot - A0A1L1RZR6
swissprot - A0A1I7Q3Y1
swissprot - A0A1D5P812
swissprot - Q5ZIP2
Ensembl - ENSGALG00000000055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor3ENSDARG00000057075Danio rerio
 Q9UHA4ENSG00000109270Homo sapiens
 O88653ENSMUSG00000091512Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015019  Ragulator complex protein LAMTOR3


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen comnitrogen compound metabolic processcell communicell communicationcellular metcellular metabolic processprimary metaprimary metabolic processregulation oregulation of molecular functionorganic subsorganic substance metabolic processcellular rescellular response to stimulusmacromoleculmacromolecule localizationcellular loccellular localizationresponse to response to endogenous stimulusresponse to response to chemical
protein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingprotein bindingenzyme regulator activityenzyme regulator activity
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019209 kinase activator activity IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
MAP2K and MAPK activation
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000029881 LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / complex






 

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