ENSGALG00000029881


Gallus gallus
regulationLAMTOR2activityactivationcellularcomplexmtorsignallingroadblocklamtordomainmapkkcellgrowthtorsignalingproteinlocalizationmolecularfunctionresponseaminoacidstimuluslateendosomeragulatorguanyl-nucleotideexchangefactorprotein-containing

Features
Gene ID: ENSGALG00000029881
  
Biological name :LAMTOR2
  
Synonyms : LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  
Possible biological names infered from orthology : Q9JHS3 / Q9Y2Q5 / Ragulator complex protein LAMTOR2
  
Species: Gallus gallus
  
Chr. number: 25
Strand: 1
Band:
Gene start: 815282
Gene end: 817762
  
Corresponding Affymetrix probe sets: Gga.10377.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058190
NCBI entrez gene - 100859842     See in Manteia.
RefSeq - XM_015298343
swissprot - A0A1D5PYY2
Ensembl - ENSGALG00000029881
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor2ENSDARG00000039872Danio rerio
 Q9Y2Q5ENSG00000116586Homo sapiens
 Q9JHS3ENSMUSG00000028062Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004942  Roadblock/LAMTOR2 domain


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationcell growthmacromolecule localizationcellular localizationresponse to endogenous stimulusresponse to chemicalnitrogen cnitrogen compound metabolic processcell commucell communicationcellular mcellular metabolic processprimary meprimary metabolic processregulationregulation of molecular functionorganic suorganic substance metabolic processcellular rcellular response to stimuluscellular ccellular component organizationcell growtcell growthmacromolecmacromolecule localizationcellular lcellular localizationresponse tresponse to endogenous stimulusresponse tresponse to chemical
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
MAP2K and MAPK activation
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000000055 Q5ZIP2 / LAMTOR3 / Ragulator complex protein LAMTOR3 / O88653* / Q9UHA4* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3*  / complex
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction






 

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