ENSGALG00000017706


Gallus gallus

Features
Gene ID: ENSGALG00000017706
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : P20936 / RASA1 / RAS p21 protein activator 1
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 61011125
Gene end: 61071967
  
Corresponding Affymetrix probe sets: Gga.14265.1.A1_at (Chicken Array)   Gga.14265.1.S1_at (Chicken Array)   Gga.18343.1.S1_s_at (Chicken Array)   GgaAffx.25289.1.S1_at (Chicken Array)   GgaAffx.25289.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025167
NCBI entrez gene - 427327     See in Manteia.
RefSeq - XM_424907
swissprot - F1NCI3
Ensembl - ENSGALG00000017706
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasa1aENSDARG00000035535Danio rerio
 rasa1bENSDARG00000073665Danio rerio
 RASA1ENSG00000145715Homo sapiens
 Rasa1ENSMUSG00000021549Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASAL2 / RAS protein activator like 2 / Q9UJF2*ENSGALG0000000432316
DAB2IP / DAB2 interacting protein / Q3UHC7* / Q5VWQ8* / Disabled homolog 2-interacting protein *ENSGALG0000000141915
RASA4 / Q6PFQ7* / RASA4B* / C9J798* / O43374* / RAS p21 protein activator 4* / RAS p21 protein activator 4B*ENSGALG0000000187611
RASAL1 / RAS protein activator like 1 / O95294* / Q9Z268* / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA.*ENSGALG0000000815010
RASA3 / RAS p21 protein activator 3 / Q14644* / Q60790* / Ras GTPase-activating protein 3 *ENSGALG0000001681710
RASA2 / RAS p21 protein activator 2 / P58069* / Q15283* / Ras GTPase-activating protein 2 *ENSGALG000000028509
ENSGALG000000368869


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR028554  Ras GTPase-activating protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / complex / reaction






 

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