ENSGALG00000008150


Gallus gallus
regulationRASAL1domainrasgtpaseproteinsignaltransductionactivitygtpase-activatingczincfingerbtkmotifpleckstrinhomologyrhoactivationph-likesuperfamilyconservedsiterasgap-activating-likeintracellularcellularresponsecalciumiondendriteextension

Features
Gene ID: ENSGALG00000008150
  
Biological name :RASAL1
  
Synonyms : RASAL1 / RAS protein activator like 1
  
Possible biological names infered from orthology : Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA. / O95294 / Q9Z268
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 11256379
Gene end: 11267964
  
Corresponding Affymetrix probe sets: GgaAffx.11220.1.S1_at (Chicken Array)   GgaAffx.5112.1.S1_at (Chicken Array)   GgaAffx.9127.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013224
Ensembl peptide - ENSGALP00000047513
NCBI entrez gene - 771057     See in Manteia.
RefSeq - XM_015294885
swissprot - A0A1D5P4A5
swissprot - F1NDA4
Ensembl - ENSGALG00000008150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasal1bENSDARG00000041515Danio rerio
 O95294ENSG00000111344Homo sapiens
 Q9Z268ENSMUSG00000029602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASA4 / Q6PFQ7* / RASA4B* / C9J798* / O43374* / RAS p21 protein activator 4* / RAS p21 protein activator 4B*ENSGALG0000000187646
RASA3 / RAS p21 protein activator 3 / Q14644* / Q60790* / Ras GTPase-activating protein 3 *ENSGALG0000001681730
RASA2 / RAS p21 protein activator 2 / P58069* / Q15283* / Ras GTPase-activating protein 2 *ENSGALG0000000285029
DAB2IP / DAB2 interacting protein / Q3UHC7* / Q5VWQ8* / Disabled homolog 2-interacting protein *ENSGALG0000000141919
RASAL2 / RAS protein activator like 2 / Q9UJF2*ENSGALG0000000432319
RASA1* / P20936* / RAS p21 protein activator 1*ENSGALG0000001770614
ENSGALG000000368861


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR028555  RasGAP-activating-like protein 1


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicationcellular response to stimulusregulation of molecular functionresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthcell communicatcell communicationcellular responcellular response to stimulusregulation of mregulation of molecular functionresponse to cheresponse to chemicalcellular componcellular component organizationanatomical struanatomical structure developmentcellular develocellular developmental processcell growthcell growthdevelopmental gdevelopmental growth
enzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activitylipid bindingion bindingenzyme regulator activityenzyme regulator activitylipid bindinglipid bindingion bindingion binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005543 phospholipid binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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