ENSGALG00000026692


Gallus gallus

Features
Gene ID: ENSGALG00000026692
  
Biological name :NRAS
  
Synonyms : GTPase NRas precursor / NRAS
  
Possible biological names infered from orthology : neuroblastoma ras oncogene / NRAS proto-oncogene, GTPase / P01111
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 3906425
Gene end: 3912847
  
Corresponding Affymetrix probe sets: Gga.18182.1.A1_at (Chicken Array)   Gga.18182.1.S1_at (Chicken Array)   GgaAffx.1383.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043468
NCBI entrez gene - 419885     See in Manteia.
RefSeq - NM_001012549
RefSeq Peptide - NP_001012567
swissprot - A0A1I7Q453
Ensembl - ENSGALG00000026692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrasENSDARG00000038225Danio rerio
 NRASENSG00000213281Homo sapiens
 NrasENSMUSG00000027852Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*ENSGALG0000003094388
H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*ENSGALG0000002926085
H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*ENSGALG0000003452685
RRAS2 / RAS related 2 / P62070* / P62071* / Ras-related protein R-Ras2 *ENSGALG0000000599853
MRAS / muscle RAS oncogene homolog / O08989* / O14807* / muscle and microspikes RAS*ENSGALG0000001159253
RALB / RAS like proto-oncogene B / P11234* / Q9JIW9* / Ras-related protein Ral-B *ENSGALG0000002649348
RALA / RAS like proto-oncogene A / P11233* / P63321* / Ras-related protein Ral-A *ENSGALG0000003189348
RERG / RAS like estrogen regulated growth inhibitor / Q8R367* / Q96A58* / Ras-related and estrogen-regulated growth inhibitor *ENSGALG0000002818635
ENSGALG0000002777834
RASL11A / RAS like family 11 member A / Q6IMB1* / Q6T310* / Ras-like protein family member 11A *ENSGALG0000001709930
GEM / GTP-binding protein GEM / P55040* / P55041* / GTP binding protein overexpressed in skeletal muscle*ENSGALG0000003250630
RASL12 / RAS like family 12 / Q08AT1* / Q9NYN1* / Ras-like protein family member 12 *ENSGALG0000000734929
REM1 / RRAD and GEM like GTPase 1 / O35929* / O75628* / GTP-binding protein REM 1 *ENSGALG0000004560229
RRAD / GTP-binding protein RAD / P55042* / Ras-related associated with diabetes* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSGALG0000000514028
ENSGALG0000000771028
RERGL / RERG like / Q9H628* / RERG/RAS-like*ENSGALG0000001311228
RASL11B / RAS like family 11 member B / Q922H7* / Q9BPW5* / Ras-like protein family member 11B *ENSGALG0000001394826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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