ENSGALG00000014184


Gallus gallus
smadtranscriptionsignalingdomainfactorreceptordwarfin-typemadhomologysuperfamilydna-templatedactivitydownregulationtgf-betafhamhdwarfinsmad-likeregulationtransforminggrowthbetapathwayintracellularnucleuscomplexcytoplasmdnabindingdna-binding

Features
Gene ID: ENSGALG00000014184
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 2 / Q15796 / Q62432 / SMAD2 / SMAD family member 2
  
Species: Gallus gallus
  
Chr. number: W
Strand: -1
Band:
Gene start: 3908079
Gene end: 3957937
  
Corresponding Affymetrix probe sets: Gga.12496.1.A1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043990
Ensembl peptide - ENSGALP00000022898
NCBI entrez gene - 769000     See in Manteia.
RefSeq - XM_015300444
RefSeq - XM_015300442
RefSeq - XM_015300443
RefSeq - XM_001232180
swissprot - H9L0G3
swissprot - A0A1D5NUH3
Ensembl - ENSGALG00000014184
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad2ENSDARG00000006389Danio rerio
 SMAD2ENSG00000175387Homo sapiens
 Smad2ENSMUSG00000024563Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000003600199
SMAD3 / mothers against decapentaplegic homolog 3 / P84022* / Q8BUN5* / SMAD family member 3*ENSGALG0000003570185
SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*ENSGALG0000000630961
SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*ENSGALG0000000997760
SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*ENSGALG0000001705060
SMAD4* / P97471* / Q13485* / SMAD family member 4* / Mothers against decapentaplegic homolog 4 *ENSGALG0000003941737
SMAD6 / mothers against decapentaplegic homolog 6 / O35182* / O43541* / SMAD family member 6*ENSGALG0000002589824
SMAD7B / Gallus gallus TGF-beta signal pathway antagonist Smad7 (SMAD7B), mRNA. / SMAD7* / O35253* / O15105* / SMAD family member 7*ENSGALG0000002954523
SMAD7* / O15105* / O35253* / SMAD family member 7*ENSGALG0000003716022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compounitrogen compound metabolic processbiosynthetic prbiosynthetic processcellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcell communicatcell communicationresponse to endresponse to endogenous stimulusresponse to cheresponse to chemicalcellular responcellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityDNA-binding transcription factor activity
cellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellcellorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001042 MTMR4 / myotubularin related protein 4 / Q91XS1* / Q9NYA4* / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA.*  / complex / reaction
 ENSGALG00000001722 E2F4 / E2F transcription factor 4 / Q16254* / Q8R0K9* / Transcription factor E2F4 *  / complex / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex / reaction
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000024081 TGIF2 / TGFB induced factor homeobox 2 / Q8C0Y1* / Q9GZN2*  / complex / reaction
 ENSGALG00000010412 WWTR1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSGALG00000001229 SKI / ski oncogene / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSGALG00000001976 TRIM33 / tripartite motif containing 33 / Q9UPN9*  / complex / reaction
 ENSGALG00000010613 ZFYVE9 / zinc finger FYVE-type containing 9 / O95405* / zinc finger, FYVE domain containing 9*  / reaction
 ENSGALG00000011442 Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000014795 TGIF1 / Q90655 / Homeobox protein AKR / Q15583* / P70284* / TGFB induced factor homeobox 1*  / complex / reaction
 ENSGALG00000011917 PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A / P35813* / P49443* / protein phosphatase 1A, magnesium dependent, alpha isoform*  / complex / reaction
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex / reaction
 ENSGALG00000015297 FOXO3 / forkhead box O3 / O43524* / Q9WVH4* / Forkhead box protein O3 *  / complex / reaction
 ENSGALG00000012207 CCNT2 / cyclin T2 / O60583* / Q7TQK0*  / reaction
 ENSGALG00000017104 CDK8 / cyclin dependent kinase 8 / P49336* / Q8R3L8*  / reaction
 ENSGALG00000041257 ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *  / reaction
 ENSGALG00000025759 TFDP2 / transcription factor Dp-2 / Q14188*  / complex / reaction
 ENSGALG00000029599 ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *  / reaction
 ENSGALG00000015471 CCNC / P55168 / Cyclin-C / P24863* / Q62447*  / reaction
 ENSGALG00000035487 SP1 / Sp1 transcription factor / O89090* / P08047* / Transcription factor Sp1 *  / complex / reaction
 ENSGALG00000038915 E2F5 / transcription factor E2F5 / Q15329* / Q61502* / E2F transcription factor 5*  / complex / reaction
 ENSGALG00000035576 CDK9 / Q5ZKN1 / Cyclin-dependent kinase 9 / P50750* / Q99J95*  / reaction






 

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