ENSGALG00000001042


Gallus gallus

Features
Gene ID: ENSGALG00000001042
  
Biological name :MTMR4
  
Synonyms : MTMR4 / myotubularin related protein 4
  
Possible biological names infered from orthology : Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA. / Q91XS1 / Q9NYA4
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 615601
Gene end: 657520
  
Corresponding Affymetrix probe sets: GgaAffx.681.1.S1_at (Chicken Array)   GgaAffx.681.2.S1_s_at (Chicken Array)   GgaAffx.681.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001554
Ensembl peptide - ENSGALP00000046056
NCBI entrez gene - 417472     See in Manteia.
RefSeq - XM_015295931
RefSeq - XM_015295932
RefSeq - XM_015295933
RefSeq - XM_415720
swissprot - E1BQV8
swissprot - A0A1D5P082
Ensembl - ENSGALG00000001042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTMR4ENSG00000108389Homo sapiens
 Mtmr4ENSMUSG00000018401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTMR3 / myotubularin related protein 3 / Q13615*ENSGALG0000000805147
MTMR2 / Q5ZIV1 / Myotubularin-related protein 2 / Q13614* / Q9Z2D1*ENSGALG0000001720017
MTMR8 / myotubularin-related protein 8 / Q96EF0*ENSGALG0000000759016
MTMR1 / myotubularin related protein 1 / Q13613* / Q9Z2C4*ENSGALG0000000908516
MTMR6 / myotubularin related protein 6 / Q8VE11* / Q9Y217*ENSGALG0000001711216
SBF1 / SET binding factor 1 / O95248* / Q6ZPE2*ENSGALG0000004317816
SBF2 / SET binding factor 2 / Q86WG5*ENSGALG0000000571615
MTMR9 / myotubularin-related protein 9 / Q96QG7* / Q9Z2D0*ENSGALG0000001664914
ENSGALG0000000331312
MTM1 / myotubularin 1 / Q13496* / Q9Z2C5* / X-linked myotubular myopathy gene 1*ENSGALG0000000909610
MTMR7* / Q9Y216* / Q9Z2C9* / myotubularin related protein 7*ENSGALG000000136419
MTMR7* / Q9Y216* / Q9Z2C9* / myotubularin related protein 7*ENSGALG000000360214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR010569  Myotubularin-like phosphatase domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017455  Zinc finger, FYVE-related
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030590  Myotubularin-related protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0005768 endosome IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction






 

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