ENSGALG00000029402


Gallus gallus

Features
Gene ID: ENSGALG00000029402
  
Biological name :AXIN1
  
Synonyms : AXIN1
  
Possible biological names infered from orthology : O15169
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 12212172
Gene end: 12280905
  
Corresponding Affymetrix probe sets: Gga.464.1.S1_at (Chicken Array)   Gga.464.2.A1_at (Chicken Array)   Gga.464.2.S1_a_at (Chicken Array)   Gga.464.2.S1_s_at (Chicken Array)   GgaAffx.20094.1.S1_s_at (Chicken Array)   GgaAffx.4658.1.A1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047150
Ensembl peptide - ENSGALP00000059288
Ensembl peptide - ENSGALP00000054296
NCBI entrez gene - 395786     See in Manteia.
RefSeq - NM_204944
RefSeq - XM_015294136
RefSeq - XM_015294137
RefSeq Peptide - NP_990275
swissprot - A0A1L1RKM1
swissprot - A0A1D5PN57
swissprot - A0A1D5P395
Ensembl - ENSGALG00000029402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 axin1ENSDARG00000102964Danio rerio
 AXIN1ENSG00000103126Homo sapiens
 Axin1ENSMUSG00000024182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AXIN2 / O88566* / Q9Y2T1*ENSGALG0000003920044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR014936  Axin beta-catenin binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR029797  Axin-1
 IPR032101  Axin-1/2, tankyrase-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0070411 I-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001600 DVL1 / dishevelled segment polarity protein 1 / O14640* / P51141* / Segment polarity DVL-1 *  / complex / reaction
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex / reaction
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / complex / reaction
 ENSGALG00000014614 TNKS2 / tankyrase-2 / Q3UES3* / Q9H2K2*  / complex / reaction
 ENSGALG00000043164 TNKS / tankyrase-1 / O95271* / Q6PFX9* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / complex / reaction
 ENSGALG00000026820 RNF146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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