ENSGALG00000042657


Gallus gallus

Features
Gene ID: ENSGALG00000042657
  
Biological name :WNT3A
  
Synonyms : Protein Wnt-3a / Q2LMP1 / WNT3A
  
Possible biological names infered from orthology : P27467 / P56704 / wingless-type MMTV integration site family, member 3A / Wnt family member 3A
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 2498228
Gene end: 2581084
  
Corresponding Affymetrix probe sets: Gga.209.1.S1_a_at (Chicken Array)   Gga.209.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057582
Ensembl peptide - ENSGALP00000045045
NCBI entrez gene - 395396     See in Manteia.
RefSeq - NM_001171601
RefSeq - NM_204675
RefSeq Peptide - NP_001165072
RefSeq Peptide - NP_990006
swissprot - Q2LMP1
swissprot - A0A1D5PX88
Ensembl - ENSGALG00000042657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt3aENSDARG00000058822Danio rerio
 WNT3AENSG00000154342Homo sapiens
 Wnt3aENSMUSG00000009900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT3 / Wnt family member 3 / P17553* / P56703* / wingless-type MMTV integration site family, member 3*ENSGALG0000000107980
WNT7A / Wnt family member 7A / O00755* / P24383* / wingless-type MMTV integration site family, member 7A*ENSGALG0000000512341
WNT5B / protein Wnt-5b precursor / Q9H1J7* / P22726* / Wnt family member 5B* / wingless-type MMTV integration site family, member 5B*ENSGALG0000001299841
WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*ENSGALG0000003416841
WNT7B / Q3L254 / Protein Wnt-7b / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSGALG0000003625541
WNT4 / P49337 / Protein Wnt-4 / P56705* / P22724* / Wnt family member 4* / wingless-type MMTV integration site family, member 4*ENSGALG0000004170841
WNT2B / O70283* / Q93097* / Wnt family member 2B* / wingless-type MMTV integration site family, member 2B*ENSGALG0000003419640
WNT2 / Wnt family member 2 / P09544* / P21552* / wingless-type MMTV integration site family, member 2*ENSGALG0000003017339
WNT16 / Wnt family member 16 / Q9QYS1* / Q9UBV4* / wingless-type MMTV integration site family, member 16*ENSGALG0000002806938
WNT6 / protein Wnt-6 / Q9Y6F9* / P22727* / Wnt family member 6* / wingless-type MMTV integration site family, member 6*ENSGALG0000001135837
WNT11BENSGALG0000000440136
WNT11 / P49339 / Protein Wnt-11 / P48615* / O96014* / Wnt family member 11* / wingless-type MMTV integration site family, member 11*ENSGALG0000000083933


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009141  Wnt-3 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation TAS
 biological_processGO:0010387 COP9 signalosome assembly IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010831 positive regulation of myotube differentiation IDA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0021874 Wnt signaling pathway involved in forebrain neuroblast division IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033278 cell proliferation in midbrain IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035108 limb morphogenesis NAS
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IDA
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048263 determination of dorsal identity TAS
 biological_processGO:0048337 positive regulation of mesodermal cell fate specification IEA
 biological_processGO:0048343 paraxial mesodermal cell fate commitment IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IEA
 biological_processGO:0048697 positive regulation of collateral sprouting in absence of injury IEA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway NAS
 biological_processGO:0060173 limb development TAS
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0060923 cardiac muscle cell fate commitment IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0061184 positive regulation of dermatome development IEA
 biological_processGO:0061303 cornea development in camera-type eye IEP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0090245 axis elongation involved in somitogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090676 calcium ion transmembrane transport via low voltage-gated calcium channel IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation IEA
 biological_processGO:1904798 positive regulation of core promoter binding IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IEA
 biological_processGO:2000081 positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005640 nuclear outer membrane IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001600 DVL1 / dishevelled segment polarity protein 1 / O14640* / P51141* / Segment polarity DVL-1 *  / complex
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / complex / reaction
 ENSGALG00000029402 AXIN1 / O15169*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / reaction






 

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