ENSGALG00000006158


Gallus gallus

Features
Gene ID: ENSGALG00000006158
  
Biological name :ACVR2B
  
Synonyms : activin receptor type-2B precursor / ACVR2B
  
Possible biological names infered from orthology : activin A receptor type 2B / Activin receptor type-2B / P27040 / Q13705
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 5768485
Gene end: 5858475
  
Corresponding Affymetrix probe sets: Gga.764.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009931
NCBI entrez gene - 374213     See in Manteia.
RefSeq - NM_204317
RefSeq Peptide - NP_989648
swissprot - F1NCI7
Ensembl - ENSGALG00000006158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvr2baENSDARG00000044422Danio rerio
 acvr2bbENSDARG00000103108Danio rerio
 ACVR2BENSG00000114739Homo sapiens
 Acvr2bENSMUSG00000061393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244471
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144236
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845935
ENSGALG0000001205533
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730129
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125729
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200328
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221628
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959928
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563528
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001946 lymphangiogenesis IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032924 activin receptor signaling pathway IMP
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway IEA
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0048333 mesodermal cell differentiation IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060836 lymphatic endothelial cell differentiation IEA
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060841 venous blood vessel development IEA
 biological_processGO:0061298 retina vasculature development in camera-type eye IEA
 biological_processGO:0061550 cranial ganglion development IMP
 biological_processGO:1901389 negative regulation of transforming growth factor beta activation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045178 basal part of cell IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IMP


Pathways (from Reactome)
Pathway description
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / complex / reaction
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / complex
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / complex / reaction
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / complex / reaction
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000029599 ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *  / complex / reaction
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / complex / reaction
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / complex / reaction
 ENSGALG00000041257 ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *  / complex
 ENSGALG00000028770 INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / complex / reaction
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSGALG00000034616 INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*  / complex / reaction






 

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