ENSG00000149177


Homo sapiens

Features
Gene ID: ENSG00000149177
  
Biological name :PTPRJ
  
Synonyms : protein tyrosine phosphatase, receptor type J / PTPRJ / Q12913
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 47980558
Gene end: 48170841
  
Corresponding Affymetrix probe sets: 210173_at (Human Genome U133 Plus 2.0 Array)   214137_at (Human Genome U133 Plus 2.0 Array)   227396_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400010
Ensembl peptide - ENSP00000479342
Ensembl peptide - ENSP00000477933
Ensembl peptide - ENSP00000435618
Ensembl peptide - ENSP00000432686
Ensembl peptide - ENSP00000409733
NCBI entrez gene - 5795     See in Manteia.
OMIM - 600925
RefSeq - XM_017018085
RefSeq - NM_001098503
RefSeq - NM_002843
RefSeq - XM_017018083
RefSeq - XM_017018084
RefSeq Peptide - NP_001091973
RefSeq Peptide - NP_002834
swissprot - A0A087WTK0
swissprot - E9PJ83
swissprot - Q12913
swissprot - A0A087WVC6
swissprot - E9PPH3
Ensembl - ENSG00000149177
  
Related genetic diseases (OMIM): 114500 - Colon cancer, somatic, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprjaENSDARG00000033042Danio rerio
 ptprjb.1ENSDARG00000091539Danio rerio
 ptprjb.2ENSDARG00000086511Danio rerio
 PTPRJENSGALG00000006382Gallus gallus
 PtprjENSMUSG00000025314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRB / P23467 / protein tyrosine phosphatase, receptor type BENSG0000012732926
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930424
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003121
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149018
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG0000016941011
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG000001342429
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG000002041799
PTPN18 / Q99952 / protein tyrosine phosphatase, non-receptor type 18ENSG000000721358
PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12ENSG000001279478
PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1ENSG000001963968
PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2ENSG000001753547


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0043116 negative regulation of vascular permeability IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0060242 contact inhibition NAS
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045295 gamma-catenin binding IPI
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IPI
 molecular_functionGO:0070097 delta-catenin binding IPI


Pathways (from Reactome)
Pathway description
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction






 

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