ENSG00000066248


Homo sapiens
domainNGEFregulationhomologyshsuperfamilyrhogtpaseactivitydbldhreceptorsignalingpathwaydevelopmentcellproteinsignaltransductiongrowthconeguanyl-nucleotideexchangefactorpleckstrinph-likeephexin--likeg-proteincoupledmulticellular

Features
Gene ID: ENSG00000066248
  
Biological name :NGEF
  
Synonyms : neuronal guanine nucleotide exchange factor / NGEF / Q8N5V2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.1
Gene start: 232878686
Gene end: 233013272
  
Corresponding Affymetrix probe sets: 227240_at (Human Genome U133 Plus 2.0 Array)   243556_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401063
Ensembl peptide - ENSP00000387591
Ensembl peptide - ENSP00000405053
Ensembl peptide - ENSP00000264051
Ensembl peptide - ENSP00000362653
Ensembl peptide - ENSP00000387033
NCBI entrez gene - 25791     See in Manteia.
OMIM - 605991
RefSeq - XM_011510925
RefSeq - NM_001114090
RefSeq - NM_019850
RefSeq - XM_011510923
RefSeq - XM_011510924
RefSeq Peptide - NP_001107562
RefSeq Peptide - NP_062824
swissprot - H7BZ39
swissprot - H7C2C2
swissprot - Q8N5V2
swissprot - C9JTV7
Ensembl - ENSG00000066248
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngefENSDARG00000076179Danio rerio
 NGEFENSGALG00000036327Gallus gallus
 NgefENSMUSG00000026259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032735
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263232
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884428
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479027
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035635  Ephexin-1, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
cell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicationcellular response to stimulusanatomical structure developmentcellular developmental processcell deathregulation of molecular functioncellular component organizationregulation of biological qualitycell communicatiocell communicationcellular responsecellular response to stimulusanatomical structanatomical structure developmentcellular developmcellular developmental processcell deathcell deathregulation of molregulation of molecular functioncellular componencellular component organizationregulation of bioregulation of biological quality
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction






 

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