ENSMUSG00000025856


Mus musculus

Features
Gene ID: ENSMUSG00000025856
  
Biological name :Pdgfa
  
Synonyms : Pdgfa / platelet derived growth factor subunit A
  
Possible biological names infered from orthology : P04085
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 138976014
Gene end: 138997370
  
Corresponding Affymetrix probe sets: 10535043 (MoGene1.0st)   1418711_at (Mouse Genome 430 2.0 Array)   1449187_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038870
Ensembl peptide - ENSMUSP00000075463
Ensembl peptide - ENSMUSP00000106521
Ensembl peptide - ENSMUSP00000106522
NCBI entrez gene - 18590     See in Manteia.
MGI - MGI:97527
RefSeq - NM_008808
RefSeq - XM_006504659
RefSeq - XM_011240971
RefSeq Peptide - NP_032834
swissprot - G5E891
swissprot - Q99L56
Ensembl - ENSMUSG00000025856
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfaaENSDARG00000110069Danio rerio
 pdgfaaENSDARG00000109371Danio rerio
 pdgfabENSDARG00000098578Danio rerio
 PDGFAENSGALG00000003642Gallus gallus
 PDGFAENSG00000197461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*ENSMUSG0000000048944


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010512 negative regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0010544 negative regulation of platelet activation IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014910 regulation of smooth muscle cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

Allelic Composition: Pdgfatm1Cbet/Pdgfatm2Cbet,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0001184 absent alveoli "missing section of the lung in which gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

Allelic Composition: Pdgfatm1Cbet/Pdgfatm2Cbet,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm2Cbet,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: B6.129-Pdgfctm1Nagy Pdgfatm2Cbet

Allelic Composition: Pdgfatm1Cbet/Pdgfa+,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004735 enlarged thoracic cavity "increased size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: B6.129-Pdgfctm1Nagy Pdgfatm2Cbet

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010822 pneumothorax "free air or gas is present in the pleural cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Agtpbp1pcd-Tg(Dhfr)1Jwg/Agtpbp1pcd-Tg(Dhfr)1Jwg
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0014079 decreased small intestinal villus number "fewer than normal numbers of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex
 ENSMUSG00000021702 Thbs4 / Q9Z1T2 / thrombospondin 4 / P35443*  / complex / reaction
 ENSMUSG00000028047 Thbs3 / Q05895 / Thrombospondin-3 / P49746*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / complex / reaction
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000023885 Thbs2 / Q03350 / Thrombospondin-2 / P35442*  / complex / reaction






 

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