ENSMUSG00000040152


Mus musculus

Features
Gene ID: ENSMUSG00000040152
  
Biological name :Thbs1
  
Synonyms : Thbs1 / thrombospondin 1
  
Possible biological names infered from orthology : P07996
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118111876
Gene end: 118127133
  
Corresponding Affymetrix probe sets: 10474700 (MoGene1.0st)   1421811_at (Mouse Genome 430 2.0 Array)   1450377_at (Mouse Genome 430 2.0 Array)   1460302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044903
NCBI entrez gene - 21825     See in Manteia.
MGI - MGI:98737
RefSeq - NM_011580
RefSeq - NM_001313914
RefSeq Peptide - NP_001300843
RefSeq Peptide - NP_035710
swissprot - Q80YQ1
Ensembl - ENSMUSG00000040152
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs1bENSDARG00000010785Danio rerio
 THBS1ENSGALG00000009626Gallus gallus
 THBS1ENSG00000137801Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thbs2 / Q03350 / Thrombospondin-2 / P35442*ENSMUSG0000002388562
Thbs4 / Q9Z1T2 / thrombospondin 4 / P35443*ENSMUSG0000002170234
Thbs3 / Q05895 / Thrombospondin-3 / P49746*ENSMUSG0000002804734
Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*ENSMUSG0000003184932


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR028499  Thrombospondin-1
 IPR028974  TSP type-3 repeat
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002605 negative regulation of dendritic cell antigen processing and presentation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IEA
 biological_processGO:0010754 negative regulation of cGMP-mediated signaling IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032695 negative regulation of interleukin-12 production IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043652 engulfment of apoptotic cell IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA
 molecular_functionGO:0070051 fibrinogen binding IEA
 molecular_functionGO:0070052 collagen V binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001204 skin irradiation resistance "decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001348 abnormal lacrimal gland physiology 
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

 MP:0003299 gastric polyps "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005488 bronchial epithelial hyperplasia "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005490 Clara cell hyperplasia "increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:48446]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005492 acinar hypoplasia "decreased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005494 esophagogastric junction metaplasia "conversion of one differentiated cell type to another differentiated cell type at the terminal end of the esophagus and beginning of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:48446]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006266 decreased pulse pressure "decrease in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0009493 abnormal cystic duct morphology "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

 MP:0011372 decreased renal tubule apoptosis "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbs1tm1Hyn/Thbs1tm1Hyn,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013452 increased lacrimal gland apoptosis " increase in the number of cells of the lacrimal gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013462 abnormal conjunctiva goblet cell number "aberration in the number of the mucin-secreting cells found on the conjunctival epithelium; changes in goblet cell numbers are associated with alterations in tear mucin level" [MGI:Anna]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013464 decreased conjunctiva goblet cell number "fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens s syndrome" [MGI:Anna]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex / reaction
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / complex
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000027009 Itga4 / integrin subunit alpha 4 / P13612*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction






 

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