ENSMUSG00000027009


Mus musculus

Features
Gene ID: ENSMUSG00000027009
  
Biological name :Itga4
  
Synonyms : integrin subunit alpha 4 / Itga4
  
Possible biological names infered from orthology : P13612
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 79255426
Gene end: 79333123
  
Corresponding Affymetrix probe sets: 10473125 (MoGene1.0st)   1421194_at (Mouse Genome 430 2.0 Array)   1427615_at (Mouse Genome 430 2.0 Array)   1436037_at (Mouse Genome 430 2.0 Array)   1450155_at (Mouse Genome 430 2.0 Array)   1456498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099718
NCBI entrez gene - 16401     See in Manteia.
MGI - MGI:96603
RefSeq - NM_010576
RefSeq Peptide - NP_034706
swissprot - Q792F9
Ensembl - ENSMUSG00000027009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga4ENSDARG00000103056Danio rerio
 ITGA4ENSGALG00000041577Gallus gallus
 ITGA4ENSG00000115232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911542
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708726
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711126
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055525
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534825
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676825
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466425
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150724
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224324
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078923
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228423
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553322
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078622
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083022
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036922
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021021
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859621
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0003366 cell-matrix adhesion involved in ameboidal cell migration IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0050904 diapedesis IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IEA
 biological_processGO:0098657 import into cell IEA
 biological_processGO:1903039 positive regulation of leukocyte cell-cell adhesion IEA
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IEA
 biological_processGO:1990771 clathrin-dependent extracellular exosome endocytosis IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034669 integrin alpha4-beta7 complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0003823 antigen binding IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:1990405 protein antigen binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001711 abnormal placenta 
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga4tm1Jty/Itga4tm1Jty
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Itga4tm1Hyn/Itga4tm1Jty
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

Allelic Composition: Itga4tm1Mgin/Itga4tm1Mgin
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga4tm1Jty/Itga4tm1Jty
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga4tm1Jty/Itga4tm1Jty
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Itga4tm1Jty/Itga4tm1Jty
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031990 Jam3 / Q9D8B7 / Junctional adhesion molecule C / Q9BX67* / junctional adhesion molecule 3*  / complex / reaction
 ENSMUSG00000027962 Vcam1 / P29533 / vascular cell adhesion molecule 1 / P19320*  / complex / reaction
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / complex / reaction
 ENSMUSG00000053062 Jam2 / Q9JI59 / Junctional adhesion molecule B / P57087* / junctional adhesion molecule 2*  / complex / reaction
 ENSMUSG00000001281 Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*  / complex
 ENSMUSG00000020310 Q61826 / Madcam1 / Mus musculus mucosal vascular addressin cell adhesion molecule 1 (Madcam1), transcript variant 2, mRNA. / Q13477* / mucosal vascular addressin cell adhesion molecule 1*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex






 

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